Academic Journal
Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects
| العنوان: | Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects |
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| المؤلفون: | Hu, Bao-Yang, Du, Zhong-Wei, Li, Xue-Jun, Ayala, Melvin, Zhang, Su-Chun |
| بيانات النشر: | Company of Biologists |
| سنة النشر: | 2009 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | RESEARCH ARTICLES |
| الوصف: | Human embryonic stem cells (hESCs) offer a platform to bridge what we have learned from animal studies to human biology. Using oligodendrocyte differentiation as a model system, we show that sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2, NKX2.2 and SOX10 is required for sequential specification of ventral spinal OLIG2-expressing progenitors, pre-oligodendrocyte precursor cells (pre-OPCs) and OPCs from hESC-derived neuroepithelia, indicating that a conserved transcriptional network underlies OPC specification in human as in other vertebrates. However, the transition from pre-OPCs to OPCs is protracted. FGF2, which promotes mouse OPC generation, inhibits the transition of pre-OPCs to OPCs by repressing SHH-dependent co-expression of OLIG2 and NKX2.2. Thus, despite the conservation of a similar transcriptional network across vertebrates, human stem/progenitor cells may respond differently to those of other vertebrates to certain extrinsic factors. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://dev.biologists.org/cgi/content/short/136/9/1443; http://dx.doi.org/10.1242/dev.029447 |
| DOI: | 10.1242/dev.029447 |
| الاتاحة: | http://dev.biologists.org/cgi/content/short/136/9/1443 https://doi.org/10.1242/dev.029447 |
| Rights: | Copyright (C) 2009, Company of Biologists |
| رقم الانضمام: | edsbas.93991761 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/dev.029447 |
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