Academic Journal
Sentinel lymph node detection in oral cancer: a within-patient comparison between [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid
| العنوان: | Sentinel lymph node detection in oral cancer: a within-patient comparison between [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid |
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| المؤلفون: | den Toom, Inne J., Mahieu, Rutger, van Rooij, Rob, van Es, Robert J. J., Hobbelink, Monique G. G., Krijger, Gerard C., Tijink, Bernard M., de Keizer, Bart, de Bree, Remco |
| المساهمون: | University Medical Center Utrecht |
| المصدر: | European Journal of Nuclear Medicine and Molecular Imaging ; volume 48, issue 3, page 851-858 ; ISSN 1619-7070 1619-7089 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | Purpose Sentinel lymph node (SLN) biopsy has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). [ 99m Tc]Tc-tilmanocept may be of benefit in OSCC with complex lymphatic drainage patterns and close spatial relation to SLNs. Methods A prospective within-patient evaluation study was designed to compare [ 99m Tc]Tc-tilmanocept with [ 99m Tc]Tc-nanocolloid for SLN detection. A total of 20 patients with early-stage OSCC were included, who underwent lymphoscintigraphy with both tracers. Both lymphoscintigraphic images of each patient were evaluated for SLN detection and radiotracer distribution at 2–4 h post-injection. Results The injection site’s remaining radioactivity was significantly lower for [ 99m Tc]Tc-tilmanocept (29.9%), compared with [ 99m Tc]Tc-nanocolloid (60.9%; p < 0.001). Radioactive uptake in SLNs was significantly lower for [ 99m Tc]Tc-tilmanocept (1.95%) compared with [ 99m Tc]Tc-nanocolloid (3.16%; p = 0.010). No significant difference was seen in SLN to injection site ratio in radioactivity between [ 99m Tc]Tc-tilmanocept (0.066) and [ 99m Tc]Tc-nanocolloid (0.054; p = 0.232). A median of 3.0 and 2.5 SLNs were identified with [ 99m Tc]Tc-tilmanocept and [ 99m Tc]Tc-nanocolloid, respectively ( p = 0.297). Radioactive uptake in higher echelon nodes was not significantly different between [ 99m Tc]Tc-tilmanocept (0.57%) and [ 99m Tc]Tc-nanocolloid (0.86%) ( p = 0.052). A median of 2.0 and 2.5 higher echelon nodes was identified with [ 99m Tc]Tc-tilmanocept and [ 99m Tc]Tc-nanocolloid, respectively ( p = 0.083). Conclusion [ 99m Tc]Tc-tilmanocept had a higher injection site clearance, but at the same time a lower uptake in the SLN, resulting in an SLN to injection site ratio, which was not significantly different from [ 99m Tc]Tc-nanocolloid. The relatively low-radioactive uptake in SLNs of [ 99m Tc]Tc-tilmanocept may limit intraoperative detection of SLNs, but can be overcome by a higher injection dose. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00259-020-04984-8 |
| DOI: | 10.1007/s00259-020-04984-8.pdf |
| DOI: | 10.1007/s00259-020-04984-8/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s00259-020-04984-8 https://link.springer.com/content/pdf/10.1007/s00259-020-04984-8.pdf https://link.springer.com/article/10.1007/s00259-020-04984-8/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.937ACF77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00259-020-04984-8 |
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