Academic Journal
Maternal exposure to ibuprofen can affect the programming of the hypothalamus of the male offspring
| العنوان: | Maternal exposure to ibuprofen can affect the programming of the hypothalamus of the male offspring |
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| المؤلفون: | Balin, Paola da Silva, Jorge, Bárbara Campos, Leite, Andressa Rejani Ribeiro, Borges, Cibele Santos, Oba, Eunice, Silva, Erick José Ramo, de Barros, Aline Lima, Horta-Júnior, José de Anchieta Castro, Arena, Arielle Cristina |
| المساهمون: | Universidade Estadual Paulista (UNESP) |
| سنة النشر: | 2020 |
| المجموعة: | Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: | Brain sexual differentiation, Preoptic area, Prostaglandins, Sexual behavior, Sexually dimorphic nucleus |
| الوصف: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Processo FAPESP: 2016/12110-3 ; Processo FAPESP: 2017/03997-7 ; Ibuprofen, a non-steroidal anti-inflammatory drug, inhibits the activity of cyclooxygenase enzyme, leading to reduction in Prostaglandin E2 (PGE2) production. Due to the importance of PGE2 in promoting the brain masculinization in male fetus, this study aimed to evaluate the effects of in utero and lactational exposure to ibuprofen and their late repercussions on reproductive parameters in male rats. Pregnant rats were exposed to ibuprofen (10, 30 or 60 mg/kg) or vehicle (control group) per gavage daily from gestational day 15 to day 21 after birth, and late reproductive effects were assessed during the sexual development and in the reproductive adult life in the male offspring. Males exposed to ibuprofen had a decrease in body weight and anogenital distance, as well as a delay in the ages of testicular descent and preputial separation. In adulthood, there was a decrease in the Leydig cells nuclei volume, testosterone levels and percentage of normal sperm morphology. All animals exposed to ibuprofen presented male copulatory behavior, however, in the presence of another male, they also presented a female-typical behavior. Maternal exposure to ibuprofen during the sensitive windows of brain development adversely impacted the reproductive parameters of male rats, suggesting an incomplete masculinization of the hypothalamus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1096-0295 0273-2300 |
| Relation: | Regulatory Toxicology and Pharmacology; http://dx.doi.org/10.1016/j.yrtph.2020.104576; Regulatory Toxicology and Pharmacology, v. 111.; http://hdl.handle.net/11449/199938; 2-s2.0-85077661885 |
| DOI: | 10.1016/j.yrtph.2020.104576 |
| الاتاحة: | http://hdl.handle.net/11449/199938 https://doi.org/10.1016/j.yrtph.2020.104576 |
| رقم الانضمام: | edsbas.932CDDD0 |
| قاعدة البيانات: | BASE |
| تدمد: | 10960295 02732300 |
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| DOI: | 10.1016/j.yrtph.2020.104576 |