التفاصيل البيبلوغرافية
| العنوان: |
Laparoscopic versus open adhesiolysis for adhesive small bowel obstruction (LASSO):an international, multicentre, randomised, open-label trial |
| المؤلفون: |
Sallinen, V. (Ville), Di Saverio, S. (Salomone), Haukijärvi, E. (Eija), Juusela, R. (Risto), Wikström, H. (Heidi), Koivukangas, V. (Vesa), Catena, F. (Fausto), Enholm, B. (Berndt), Birindelli, A. (Arianna), Leppäniemi, A. (Ari), Mentula, P. (Panu) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2019 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| الوصف: |
Background: Although laparoscopic adhesiolysis for adhesive small bowel obstruction is being done more frequently, it is not widely accepted due to the lack of supporting evidence of its superiority over an open approach and concerns regarding its benefits. We aimed to investigate whether laparoscopic adhesiolysis was a superior treatment for adhesive small bowel obstruction compared with an open approach in terms of length of postoperative hospital stay and morbidity. Methods: In this international, multicentre, parallel, open-label trial, we randomly assigned patients (1:1) aged 18–95 years who had adhesive small bowel obstruction that had not resolved with conservative management to have either open or laparoscopic adhesiolysis. The study was done in five academic university hospitals and three community (central) hospitals in two countries (Finland [n=3 academic university hospitals; n=3 community hospitals] and Italy [n=2 academic university hospitals]). We included only patients with high likelihood of a single adhesive band in the trial; additionally, patients who had an anaesthesiological contraindication, were pregnant, living in institutionalised care, or who had a hospital stay of more than 1 week before the surgical consultation were excluded from the trial. The randomisation sequence was generated using block randomisation, with randomly varied block sizes and stratified according to centre. The primary outcome was postoperative length of hospital stay assessed at time of discharge in the modified intention-to-treat population. Findings: Between July 18, 2013, and April 9, 2018, 566 patients were assessed for eligibility, of whom 104 patients were randomly assigned to the open surgery group (n=51) or to the laparoscopy group (n=53). Of these patients, 100 were included in the modified intention-to-treat analyses (49 in the open surgery group; 51 in the laparoscopy group). The postoperative length of hospital stay for open surgery group was on average 1·3 days longer than that in the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الاتاحة: |
http://urn.fi/urn:nbn:fi-fe2020102085746 |
| Rights: |
info:eu-repo/semantics/openAccess ; © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/ ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: |
edsbas.930CA655 |
| قاعدة البيانات: |
BASE |