Academic Journal
Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring ...
| العنوان: | Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring ... |
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| المؤلفون: | Hakmaoui, Abdelmalek, Khan, Faisal, Liacini, Abdelhamid, Kaur, Amanjot, Berka, Yacine, Machraoui, Safaa, Soualhine, Hafid, Berka, Noureddine, Rais, Hanane, Admou, Brahim |
| بيانات النشر: | University of Calgary |
| سنة النشر: | 2021 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| الوصف: | Real-time genome monitoring of the SARS-CoV-2 pandemic outbreak is of utmost importance for designing diagnostic tools, guiding antiviral treatment and vaccination strategies. In this study, we present an accurate method for temporal and geographical comparison of mutational events based on GISAID database genome sequencing. Among 42523 SARS-CoV-2 genomes analyzed, we found 23202 variants compared to the reference genome. The Ti/Tv (transition/transversion) ratio was used to filter out possible false-positive errors. Transition mutations generally occurred more frequently than transversions. Our clustering analysis revealed remarkable hotspot mutation patterns for SARS-CoV-2. Mutations were clustered based on how their frequencies changed over time according to each geographical location. We observed some clusters showing a clear variation in mutation frequency and continuously evolving in the world. However, many mutations appeared in specific periods without a clear pattern over time. Various important ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.11575/prism/38976 |
| الاتاحة: | https://dx.doi.org/10.11575/prism/38976 https://prism.ucalgary.ca/handle/1880/113586 |
| Rights: | Copyright © 2021 Abdelmalek Hakmaoui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.930C1978 |
| قاعدة البيانات: | BASE |
| DOI: | 10.11575/prism/38976 |
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