Academic Journal
Respiratory-resolved five-dimensional flow cardiovascular magnetic resonance : In-vivo validation and respiratory-dependent flow changes in healthy volunteers and patients with congenital heart disease
| العنوان: | Respiratory-resolved five-dimensional flow cardiovascular magnetic resonance : In-vivo validation and respiratory-dependent flow changes in healthy volunteers and patients with congenital heart disease |
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| المؤلفون: | Elizabeth K. Weiss, Justin Baraboo, Cynthia K. Rigsby, Joshua D. Robinson, Liliana Ma, Mariana B.L. Falcão, Christopher W. Roy, Matthias Stuber, Michael Markl |
| المصدر: | Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 2, Pp 101077- (2024) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | 5D flow CMR, Respiratory-resolved flow, Real-time phase-contrast MRI, Congenital heart disease, Single ventricle disease, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: This study aimed to validate respiratory-resolved five-dimensional (5D) flow cardiovascular magnetic resonance (CMR) against real-time two-dimensional (2D) phase-contrast MRI, assess the impact of number of respiratory states, and measure the impact of respiration on hemodynamics in congenital heart disease (CHD) patients. Methods: Respiratory-resolved 5D flow MRI-derived net and peak flow measurements were compared to real-time 2D phase-contrast MRI-derived measurements in 10 healthy volunteers. Pulmonary-to-systemic flow ratios (Qp:Qs) were measured in 19 CHD patients and aortopulmonary collateral burden was measured in 5 Fontan patients. Additionally, the impact of number of respiratory states on measured respiratory-driven net flow changes was investigated in 10 healthy volunteers and 19 CHD patients (shunt physiology, n = 11, single ventricle disease [SVD], n = 8). Results: There was good agreement between 5D flow MRI and real-time 2D phase-contrast–derived net and peak flow. Respiratory-driven changes had a good correlation (rho = 0.64, p < 0.001). In healthy volunteers, fewer than four respiratory states reduced measured respiratory-driven flow changes in veins (5.2 mL/cycle, p < 0.001) and arteries (1.7 mL/cycle, p = 0.05). Respiration drove substantial venous net flow changes in SVD (64% change) and shunt patients (57% change). Respiration had significantly greater impact in SVD patients compared to shunt patients in the right and left pulmonary arteries (46% vs 15%, p = 0.003 and 59% vs 20%, p = 0.002). Qp:Qs varied by 37 ± 24% over respiration in SVD patients and 12 ± 20% in shunt patients. Aortopulmonary collateral burden varied by 118 ± 84% over respiration in Fontan patients. The smallest collateral burden was measured during active inspiration in all patients and the greatest burden was during active expiration in four of five patients. Reduced respiratory resolution blunted measured flow changes in the caval veins of shunt and SVD patients (p < 0.005). Conclusions: ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-1-09-766472-6 1-09-766472-4 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1097664724011049; https://doaj.org/toc/1097-6647; https://doaj.org/article/051ab15dbcff4b0395481a132fb4c374 |
| DOI: | 10.1016/j.jocmr.2024.101077 |
| الاتاحة: | https://doi.org/10.1016/j.jocmr.2024.101077 https://doaj.org/article/051ab15dbcff4b0395481a132fb4c374 |
| رقم الانضمام: | edsbas.930B4B9A |
| قاعدة البيانات: | BASE |
| ردمك: | 9781097664726 1097664724 |
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| DOI: | 10.1016/j.jocmr.2024.101077 |