التفاصيل البيبلوغرافية
| العنوان: |
A cross-modal genetic framework for the development and plasticity of sensory pathways |
| المؤلفون: |
Frangeul, Laura, Pouchelon, Gabrielle, Telley, Ludovic, Lefort, Sandrine, Luescher, Christian, Jabaudon, Denis |
| المصدر: |
ISSN: 0028-0836 ; Nature, vol. 538, no. 7623 (2016) p. 96-98. |
| سنة النشر: |
2016 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/616.8 |
| الوصف: |
Modality-specific sensory inputs from individual sense organs are processed in parallel in distinct areas of the neocortex. For each sensory modality, input follows a cortico-thalamo-cortical loop in which a 'first-order' exteroceptive thalamic nucleus sends peripheral input to the primary sensory cortex, which projects back to a 'higher order' thalamic nucleus that targets a secondary sensory cortex. This conserved circuit motif raises the possibility that shared genetic programs exist across sensory modalities. Here we report that, despite their association with distinct sensory modalities, first-order nuclei in mice are genetically homologous across somatosensory, visual, and auditory pathways, as are higher order nuclei. We further reveal peripheral input-dependent control over the transcriptional identity and connectivity of first-order nuclei by showing that input ablation leads to induction of higher-order-type transcriptional programs and rewiring of higher-order-directed descending cortical input to deprived first-order nuclei. These findings uncover an input-dependent genetic logic for the design and plasticity of sensory pathways, in which conserved developmental programs lead to conserved circuit motifs across sensory modalities. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/27669022; https://archive-ouverte.unige.ch/unige:94162; unige:94162 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:94162 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.930913EC |
| قاعدة البيانات: |
BASE |