Book
Ibogaine and Noribogaine
| العنوان: | Ibogaine and Noribogaine |
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| المؤلفون: | Mash, Deborah C., Karukin, Michael |
| المصدر: | The Oxford Handbook of Opioids and Opioid Use Disorder ; page 419-440 ; ISBN 9780197618431 9780197618462 |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2023 |
| الوصف: | Ibogaine is an indole alkaloid derived from the root bark of Tabernanthe iboga. The anti-addictive actions of ibogaine were first reported in the 1960s by persons using heroin. They offered personal testimonials that single oral doses of ibogaine abruptly blocked opioid withdrawal, and they remained drug-free after ibogaine exposure. Today, online forums describe ibogaine use for opioid withdrawal management by for-profit clinics and unskilled lay people, despite a lack of regulatory testing of ibogaine in human clinical trials. Discontinuation of opioid agonist therapy results in severely painful opioid withdrawal symptoms (OWS) that are followed by a persistent negative affect. For many patients seeking to discontinue opioids, the post-acute emotional disruption is a major obstacle for completion of full withdrawal. This chapter summarizes ibogaine’s clinical experience and open-label observational evidence that the drug is useful for treating the OWS and facilitating a transition to drug-free abstinence. The drug’s polypharmacy mode of action is considered in light of neuroadaptations in mu-opioid processes observed during acute withdrawal, which are mechanistically related to the protracted negative mood state that follows during opioid abstinence. Finally, the dark side of the unregulated use of ibogaine and concerns for patient safety are considered. The value proposition for development of ibogaine as a psychedelic drug product for addiction treatment will ultimately depend on the drug’s single dose regimen, benefits, risks, and safety measures demonstrated in controlled clinical trials. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-0-19-761843-1 978-0-19-761846-2 0-19-761843-X 0-19-761846-4 |
| DOI: | 10.1093/oxfordhb/9780197618431.013.16 |
| الاتاحة: | http://dx.doi.org/10.1093/oxfordhb/9780197618431.013.16 https://academic.oup.com/edited-volume/45895/chapter/430589444 |
| رقم الانضمام: | edsbas.9305619E |
| قاعدة البيانات: | BASE |
| ردمك: | 9780197618431 9780197618462 019761843X 0197618464 |
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| DOI: | 10.1093/oxfordhb/9780197618431.013.16 |