Conference
ABRomics - a digital platform on antimicrobial resistance to store, integrate, analyze and share multi-omics data
| العنوان: | ABRomics - a digital platform on antimicrobial resistance to store, integrate, analyze and share multi-omics data |
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| المؤلفون: | Marin, Pierre, Lao, Julie, Hillion, Kenzo-Hugo, Birer, Aurélien, Goué, Nadia, Bonnet, Richard, Mareuil, Fabien, Le Gorguille, Gildas, Ruppe, Etienne, Abromics, Consortium, Glaser, Philippe, Médigue, Claudine |
| المساهمون: | Institut Français de Bioinformatique (IFB-CORE), Institut National de Recherche en Informatique et en Automatique (Inria)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plateforme Auvergne Bioinformatique (AuBi), Mésocentre Clermont Auvergne, Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Nantes Université (Nantes Univ), CHU Clermont-Ferrand, Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (ABIMS), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff = Roscoff Marine Station (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff = Roscoff Marine Station (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Écologie et Évolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance (EERA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Saclay-Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Analyse Bio-Informatique pour la Génomique et le Métabolisme (LABGeM), Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage Evry (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS)-Genoscope - Centre national de séquençage Evry (GENOSCOPE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), SFBI et IFB, Campus de Beaulieu de l’Université de Rennes |
| المصدر: | JOURNÉES OUVERTES EN BIOLOGIE, INFORMATIQUE ET MATHÉMATIQUES ( JOBIM ) 2022 ; https://hal.science/hal-04369049 ; JOURNÉES OUVERTES EN BIOLOGIE, INFORMATIQUE ET MATHÉMATIQUES ( JOBIM ) 2022, Jul 2022, Rennes, France. Actes JOBIM 2022 |
| بيانات النشر: | CCSD |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | antibioresistance, genomic surveillance, FAIR data, database, Galaxy Workflow, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| جغرافية الموضوع: | Rennes, France |
| الوصف: | International audience ; Antibiotic resistance (ABR) is a major public health issue prioritized for mitigation by major international institutions, especially regarding the emergence and the global dissemination of multidrug resistant (MDR) isolates and of antibiotic resistance genes (ARGs) carried by mobile genetic elements. They are also transmitted between humans, animals and the environment, without borders. The evolution of ABR is a complex process with multiple selective forces in different environments.Genome sequences, which contain all the genetic information of an organism, can be used for molecular typing purposes with the highest resolution, the identification of ARGs and their genetic supports as well as mutations leading to a decrease in antibiotic susceptibility. Combined with epidemiological information, bacterial Whole Genome Sequencing (WGS) can enable tracking transmissions of outbreaks and identifying a source of contamination. Reinforcing the sharing of high-quality sequence data for diagnostic and epidemiological applications, together with interoperable and curated metadata, which can be integrated with other omics data, is a key requirement for understanding the complexity of spatiotemporal patterns of pathogen and ARGs transmission between compartments.Today, if more systematic genome sequencing and bioinformatics analysis can partially address such major issues, data sharing and comparison across centers, together with standardization of analytical workflows remain major bottlenecks. The ABRomics project aims to develop a secure One Health, online platform to make bacterial infectious disease (meta)genomics data and their associated clinical and epidemiological metadata accessible to a meta-network of researchers including epidemiologists, clinical microbiologists and the wider research community. It should provide the diverse communities with a user-friendly platform to store, share and analyze genomic information together with their metadata. It will also serve as a data brokering hub ... |
| نوع الوثيقة: | conference object still image |
| اللغة: | English |
| الاتاحة: | https://hal.science/hal-04369049 https://hal.science/hal-04369049v1/document https://hal.science/hal-04369049v1/file/abromics_jobim2022_4.0.pdf |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.92FA848A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |