Academic Journal
Synthesis, cytotoxicity, apoptosis-inducing activity and molecular docking studies of novel isatin–podophyllotoxin hybrids
| العنوان: | Synthesis, cytotoxicity, apoptosis-inducing activity and molecular docking studies of novel isatin–podophyllotoxin hybrids |
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| المؤلفون: | Nguyen, Ha Thanh, Van, Ket Tran, Pham-The, Hai, Le, Quang-Bao, Le-Nhat-Thuy, Giang, Dang Thi, Tuyet Anh, Hoang Thi, Phuong, Nguyen Thi, Quynh Giang, Tuan, Anh Nguyen, Vu Ngoc, Doan, Van Nguyen, Tuyen |
| المساهمون: | National Foundation for Science and Technology Development |
| المصدر: | RSC Advances ; volume 15, issue 4, page 2825-2839 ; ISSN 2046-2069 |
| بيانات النشر: | Royal Society of Chemistry (RSC) |
| سنة النشر: | 2025 |
| الوصف: | Compound 7f exhibited cytotoxicity to A549 cells, inducing apoptosis and cell cycle arrest in a dose-dependent manner. It also interacted with ATP binding sites of CDK2/cyclin A and CDK5/p25, and activated procaspase 6 through stable zinc chelation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1039/d4ra08691k |
| الاتاحة: | https://doi.org/10.1039/d4ra08691k http://pubs.rsc.org/en/content/articlepdf/2025/RA/D4RA08691K |
| Rights: | http://creativecommons.org/licenses/by-nc/3.0/ |
| رقم الانضمام: | edsbas.92E18D97 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1039/d4ra08691k |
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