Academic Journal
Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19
| العنوان: | Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19 |
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| المؤلفون: | Le, Trang T., Gutiérrez-Sacristán, Alba, Son, Jiyeon, Hong, Chuan, South, Andrew M., Beaulieu-Jones, Brett K., Loh, Ne Hooi Will, Luo, Yuan, Morris, Michele, Ngiam, Kee Yuan, Patel, Lav P., Samayamuthu, Malarkodi J., Schriver, Emily, Tan, Amelia L. M., Moore, Jason, Cai, Tianxi, Omenn, Gilbert S., Avillach, Paul, Kohane, Isaac S., Aaron, James R., Agapito, Giuseppe, Albayrak, Adem, Alessiani, Mario, Amendola, Danilo F., Angoulvant, François, Anthony, Li L. L. J., Aronow, Bruce J., Atz, Andrew, Balshi, James, Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Blanco Martínez, Alvar, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bryant, William A., Bucalo, Mauro, Burgun, Anita |
| المساهمون: | National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences, Division of Cancer Prevention, National Cancer Institute, U.S. National Library of Medicine, National Institute of Neurological Disorders and Stroke |
| المصدر: | Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, p FDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, p FDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-021-99481-9 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-021-99481-9 https://www.nature.com/articles/s41598-021-99481-9.pdf https://www.nature.com/articles/s41598-021-99481-9 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.92D8B8DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-99481-9 |
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