التفاصيل البيبلوغرافية
| العنوان: |
Liver Brain Interactions: Focus on FGF21 a Systematic Review |
| المؤلفون: |
Eva Prida, Sara Álvarez-Delgado, Raquel Pérez-Lois, Mateo Soto-Tielas, Ana Estany-Gestal, Johan Fernø, Luisa María Seoane, Mar Quiñones, Omar Al-Massadi |
| المصدر: |
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13318 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
obesity, energy balance, food intake, hypothalamus, FGF21 |
| جغرافية الموضوع: |
agris |
| الوصف: |
Fibroblast growth factor 21 is a pleiotropic hormone secreted mainly by the liver in response to metabolic and nutritional challenges. Physiologically, fibroblast growth factor 21 plays a key role in mediating the metabolic responses to fasting or starvation and acts as an important regulator of energy homeostasis, glucose and lipid metabolism, and insulin sensitivity, in part by its direct action on the central nervous system. Accordingly, pharmacological recombinant fibroblast growth factor 21 therapies have been shown to counteract obesity and its related metabolic disorders in both rodents and nonhuman primates. In this systematic review, we discuss how fibroblast growth factor 21 regulates metabolism and its interactions with the central nervous system. In addition, we also state our vision for possible therapeutic uses of this hepatic-brain axis. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms232113318 |
| DOI: |
10.3390/ijms232113318 |
| الاتاحة: |
https://doi.org/10.3390/ijms232113318 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.9274BD2F |
| قاعدة البيانات: |
BASE |