التفاصيل البيبلوغرافية
| العنوان: |
The influence of sex and chronic restraint stress on transcriptional and post-transcriptional regulations on the rat dorsal and ventral hippocampus |
| المؤلفون: |
Román Albasini, Luciano Paolo |
| المساهمون: |
Fiedler Temer, Jenny Lucy |
| بيانات النشر: |
Universidad de Chile |
| سنة النشر: |
2022 |
| المجموعة: |
Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: |
Estrés (Fisiología), Hipocampo, Cerebro--Diferencias sexuales |
| الوصف: |
Autor NO autoriza el acceso al texto completo de su documento ; Our increasing understanding of sex has unveiled its relevance for health and disease. Importantly, the search of the molecular bases that act as the foundations for sex differences in health and disease may provide novel insights to improve clinical outcomes in females and males. In neuropsychiatric disorders, sex biases are quite robust. Specially, stress-related disorders are at least twice as prevalent in females than males. A growing amount of evidence support that alterations in the hippocampus –a limbic brain area in the temporal lobe– may contribute to cognitive and affective symptoms in stressrelated disorders. Importantly, considering the sex biases in stress-related neuropsychiatric disorders and the role of the hippocampus in these disorders, it is mandatory to understand the effects of sex on hippocampal physiology and pathology. Basal sex differences in hippocampal behavior, morphology and plasticity suggest that the molecular architecture must also differ by sex. While this has been studied considering the hippocampus as a homogeneous structure, there are circuitry and molecular gradients along the hippocampal longitudinal axis that differentiates its poles: dorsal-ventral in rodents and posterioranterior in primates. However, no study has investigated the inFluence of sex on the molecular proFiles of the dorsal and ventral hippocampus, nor how they may be regulated. Chronic stress constitutes a risk factor for the majority of neuropsychiatric disorders. We have learned that chronic restraint stress triggers sex-speciFic behavioral and transcriptomic outcomes in the dorsal and ventral rat hippocampus. Nonetheless, we do not know which transcriptional and post-transcriptional regulators may produce such differences. In light of these antecedents, we propose: “Sex and chronic restraint stress inFluence the transcriptional and post-transcriptional regulators in the dorsal and ventral rat hippocampus”. To prove this hypothesis, we First ... |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://repositorio.uchile.cl/handle/2250/193037 |
| الاتاحة: |
https://repositorio.uchile.cl/handle/2250/193037 |
| رقم الانضمام: |
edsbas.9265FA1F |
| قاعدة البيانات: |
BASE |