التفاصيل البيبلوغرافية
| العنوان: |
Nanoparticle-based rifampicin delivery system development |
| المؤلفون: |
Motiei, Marjan, Pleno de Gouveia, Luis, Šopík, Tomáš, Vícha, Robert, Škoda, David, Císař, Jaroslav, Khalili, Reza, Domincová Bergerová, Eva, Münster, Lukáš, Fei, Haojie, Sedlařík, Vladimír, Sáha, Petr |
| المصدر: |
Molecules |
| بيانات النشر: |
MDPI |
| سنة النشر: |
2021 |
| المجموعة: |
Tomas Bata University Zlin: TBU publications / Univerzita Tomáše Bati ve Zlíně |
| مصطلحات موضوعية: |
rifampicin, polyelectrolyte nanoparticles, ascorbic acid, alkaline pH |
| الوصف: |
The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by H-1 NMR, elemental analysis, FT-IR, XRD, DSC, DLS, SEM, TEM, UV/Vis spectrophotometry, and HPLC. According to the results, the nanostructures exhibited different morphologies but similar physicochemical properties and release profiles. It was also hypothesized that the simultaneous use of the nanosystem and an antioxidant could be therapeutically beneficial. Therefore, the simultaneous effects of ascorbic acid and PENs were evaluated on the release profile and degradation of rifampicin, in which the results confirmed their synergistic protective effect at pH 8.5, as opposed to pH 7.4. Overall, this study highlighted the benefits of nanoparticulate development in the presence of antioxidants, at alkaline pH, as an efficient approach for decreasing rifampicin degradation. ; Ministry of Education, Youth and Sport of the Czech Republic-DKRVO [RP/CPS/2020/005] |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
https://www.mdpi.com/1420-3049/26/7/2067; Molecules; http://publikace.k.utb.cz/handle/10563/1010307 |
| الاتاحة: |
http://publikace.k.utb.cz/handle/10563/1010307 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ ; openAccess |
| رقم الانضمام: |
edsbas.9262868F |
| قاعدة البيانات: |
BASE |