التفاصيل البيبلوغرافية
| العنوان: |
LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers |
| المؤلفون: |
Sundqvist, Benjamin, Sihto, Harri, von Willebrand, Maria, Böhling, Tom, Koljonen, Virve |
| المساهمون: |
Department of Pathology, Medicum, University of Helsinki, HUSLAB, Tom Böhling / Principal Investigator, Department of Surgery, HUS Musculoskeletal and Plastic Surgery, Plastiikkakirurgian yksikkö |
| بيانات النشر: |
Springer |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Merkel cell carcinoma, Stem cell, Hair follicle, LRIG1, Immunohistochemistry, HUMAN-PAPILLOMAVIRUS STATUS, POLYOMAVIRUS INFECTION, T-ANTIGEN, IN-VIVO, DIFFERENTIATION, HISTOGENESIS, SKIN, ORIGIN, GROWTH, Biomedicine |
| الوصف: |
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin. The cell of origin of MCC is thus far unknown and proposed cells of origin include Merkel cells, pro-/pre- or pre-B cells, epithelial stem cells, and dermal stem cells. In this study, we aimed to shed further light on the possibility that a subset of MCC tumors arise from epithelial stem cells of the skin by examining the expression of hair follicle and epidermal stem cell markers in MCC and normal human skin. We also aimed to elucidate any correlation between the expression of these markers and tumor Merkel cell polyomavirus (MCPyV) status or other clinicopathological characteristics or patient survival. Expression of CK19, SOX9, LGR5, and LRIG1 in MCC and normal human skin was studied by immunohistochemistry, and the staining patterns or intensities were statistically correlated with patient, tumor, MCPyV, and survival parameters. In a cohort of 137 cases of MCC, we observed dot-like immunoexpression of CK19 in 30 cases (22.1%) and homogeneous expression in 103 cases (75.7%). We also observed positive immunoexpression of SOX9 in 21 cases (15.3%), LGR5 in 118 cases (86.1%), and LRIG1 in 117 cases (86.0%). Immunoexpression of LRIG1 was found to correlate with better overall and MCC-specific survival. We observed frequent immunoexpression of several hair follicle and epidermal stem cell markers in MCC and found LRIG1 to be a positive prognostic marker in MCC. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Suomen tiedeseura; Relanderin säätiö; Sarcoma Foundation of America; Mary ja Georg C. Ehrnroothin säätiö; Avohoidon Tutkimussäätiö sr; Open access funding provided by University of Helsinki including Helsinki University Central Hospital. This study was supported by Jane and Aatos Erkko Foundation (4706174), Medicinska Understodsforeningen Liv och Halsa r.f. (4706019), Finska Lakaresallskapet (4708210), and University of Helsinki Funds (73604111).; Sundqvist , B , Sihto , H , von Willebrand , M , Böhling , T & Koljonen , V 2021 , ' LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers ' , Virchows Archiv , vol. 479 , no. 6 , pp. 1197-1207 . https://doi.org/10.1007/s00428-021-03158-7; ORCID: /0000-0003-0398-4829/work/108463282; ORCID: /0000-0001-5265-5509/work/116550036; ORCID: /0000-0002-6316-1421/work/125259355; http://hdl.handle.net/10138/340546; 0551da30-3607-474f-a823-fc03b59b9300; 000679781000001 |
| الاتاحة: |
http://hdl.handle.net/10138/340546 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.9238DB19 |
| قاعدة البيانات: |
BASE |