التفاصيل البيبلوغرافية
| العنوان: |
Image_4_Predictive Value of Combined Preoperative Carcinoembryonic Antigen Level and Ki-67 Index in Patients With Gastric Neuroendocrine Carcinoma After Radical Surgery.tiff |
| المؤلفون: |
Jianwei Xie (597431), YaJun Zhao (10218605), Yanbing Zhou (3442439), Qingliang He (1492285), Hankun Hao (10218608), Xiantu Qiu (10218611), Gang Zhao (161405), Yanchang Xu (1950964), Fangqin Xue (143982), Jinping Chen (237709), Guoqiang Su (4744521), Ping Li (31981), Chao-Hui Zheng (415116), Chang-Ming Huang (415113) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, gastric neuroendocrine carcinoma, carcinoembryonic antigen (CEA), Ki-67, prognosis, nomogram |
| الوصف: |
Précis We present a valid and reproducible nomogram that combined the TNM stage as well as the Ki-67 index and carcinoembryonic antigen levels; the nomogram may be an indispensable tool to help predict individualized risks of death and help clinicians manage patients with gastric neuroendocrine carcinoma. Background To analyze the long-term outcomes of patients with grade 3 GNEC who underwent curative surgery and investigated whether the combination of carcinoembryonic antigen (CEA) levels and Ki-67 index can predict the prognosis of patients with gastric neuroendocrine carcinoma (GNEC) and constructed a nomogram to predict patient survival. Methods In the training cohort, data were collected from 405 patients with GNEC after radical surgery at seven Chinese centers. A nomogram was constructed to predict long-term prognosis. Data for the validation cohort were collected from 305 patients. Results The 5-year overall survival (OS) was worse in the high CEA group than in the normal CEA group (40.5% vs. 55.2%, p = 0.013). The 5-year OS was significantly worse in the high Ki-67 index group than in the low Ki-67 index group (47.9% vs. 57.2%, p = 0.012). Accordingly, we divided the whole cohort into a KC(-) group (low Ki-67 index and normal CEA) and KC(+) group (high Ki-67 index and/or high CEA). The KC(+) group had a worse prognosis than the KC(-) group (64.6% vs. 46.8%, p < 0.001). KC(+) and the AJCC 8 th stage were independent factors for OS. Then, we combined KC status and the AJCC 8 th stage to establish a nomogram; the C-index and area under the curve (AUC) were higher for the nomogram than for the AJCC 8 th stage (C-index: 0.660 vs. 0.635, p = 0.005; AUC: 0.700 vs. 0.675, p = 0.020). The calibration curve verified that the nomogram had a good predictive value, with similar findings in the validation groups. Conclusions The nomogram based on KC status and the AJCC 8 th stage predicted the prognosis of patients with GNEC well. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Image_4_Predictive_Value_of_Combined_Preoperative_Carcinoembryonic_Antigen_Level_and_Ki-67_Index_in_Patients_With_Gastric_Neuroendocrine_Carcinoma_After_Radical_Surgery_tiff/14141297 |
| DOI: |
10.3389/fonc.2021.533039.s004 |
| الاتاحة: |
https://doi.org/10.3389/fonc.2021.533039.s004 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.921D4ED1 |
| قاعدة البيانات: |
BASE |