Academic Journal
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis
| العنوان: | Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis |
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| المؤلفون: | Griffin, Jan M., Rosenblum, Hannah, Maurer, Mathew S. |
| المصدر: | Circulation Research ; volume 128, issue 10, page 1554-1575 ; ISSN 0009-7330 1524-4571 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2021 |
| الوصف: | Often considered a rare disease, cardiac amyloidosis is increasingly recognized by practicing clinicians. The increased rate of diagnosis is in part due the aging of the population and increasing incidence and prevalence of cardiac amyloidosis with advancing age, as well as the advent of noninvasive methods using nuclear scintigraphy to diagnose transthyretin cardiac amyloidosis due to either variant or wild type transthyretin without a biopsy. Perhaps the most important driver of the increased awareness is the elucidation of the biologic mechanisms underlying the pathogenesis of cardiac amyloidosis which have led to the development of several effective therapies with differing mechanisms of actions. In this review, the mechanisms underlying the pathogenesis of cardiac amyloidosis due to light chain (AL) or transthyretin (ATTR) amyloidosis are delineated as well as the rapidly evolving therapeutic landscape that has emerged from a better pathophysiologic understanding of disease development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1161/circresaha.121.318187 |
| DOI: | 10.1161/CIRCRESAHA.121.318187 |
| الاتاحة: | http://dx.doi.org/10.1161/circresaha.121.318187 https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.121.318187 |
| رقم الانضمام: | edsbas.91BFF0F4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/circresaha.121.318187 |
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