Academic Journal
Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease
| العنوان: | Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease |
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| المؤلفون: | Mccolgan, Peter, Razi, Adeel, Gregory, Sarah, Seunarine, Kiran, K, Dürr, Alexandra, A.C. Roos, Raymund, Leavitt, Blair, R, Scahill, Rachael, I, Clark, Chris, A, Langbehn, Doug, R, Rees, Geraint, Tabrizi, Sarah, J |
| المساهمون: | Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1065-9471. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Huntington's disease, brain network, depression, functional MRI, diffusion tractography r r, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub‐network associated with depression was identified in a data‐driven fashion and network‐based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28294457; hal-04423324; https://hal.science/hal-04423324; https://hal.science/hal-04423324/document; https://hal.science/hal-04423324/file/Human%20Brain%20Mapping%20-%202017%20-%20McColgan%20-%20Structural%20and%20functional%20brain%20network%20correlates%20of%20depressive%20symptoms%20in.pdf; PUBMED: 28294457; PUBMEDCENTRAL: PMC5434856 |
| DOI: | 10.1002/hbm.23527 |
| الاتاحة: | https://hal.science/hal-04423324 https://hal.science/hal-04423324/document https://hal.science/hal-04423324/file/Human%20Brain%20Mapping%20-%202017%20-%20McColgan%20-%20Structural%20and%20functional%20brain%20network%20correlates%20of%20depressive%20symptoms%20in.pdf https://doi.org/10.1002/hbm.23527 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.919E7059 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hbm.23527 |
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