Academic Journal
Cognitive training modulates brain hypersynchrony in a population at risk for Alzheimer’s disease
| العنوان: | Cognitive training modulates brain hypersynchrony in a population at risk for Alzheimer’s disease |
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| المؤلفون: | Suárez Méndez, Isabel, Bruña Fernández, Ricardo, López Sanz, David, Montejo, Pedro, Montenegro Peña, María Mercedes, Delgado Losada, María Luisa, Marcos Dolado, Alberto, López Sánchez, Ramón, Maestu Unturbe, Fernando |
| بيانات النشر: | IOS Press |
| سنة النشر: | 2022 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | Cognitive decline, Functional neuroimaging, Intervention study, Longitudinal studies, Magnetoencephalography, Neurociencias (Medicina), 2490 Neurociencias, 2402.15 Envejecimiento Somático |
| الوصف: | Background: Recent studies demonstrated that brain hypersynchrony is an early sign of dysfunction in Alzheimer's disease (AD) that can represent a proxy for clinical progression. Conversely, non-pharmacological interventions, such as cognitive training (COGTR), are associated with cognitive gains that may be underpinned by a neuroprotective effect on brain synchrony. Objective: To study the potential of COGTR to modulate brain synchrony and to eventually revert the hypersynchrony phenomenon that characterizes preclinical AD. Methods: The effect of COGTR was examined in a sample of healthy controls (HC, n = 41, 22 trained) and individuals with subjective cognitive decline (SCD, n = 49, 24 trained). Magnetoencephalographic activity and neuropsychological scores were acquired before and after a ten-week COGTR intervention aimed at improving cognitive function and daily living performance. Functional connectivity (FC) was analyzed using the phase-locking value. A mixed-effects ANOVA model with factors time (pre-intervention/post-intervention), training (trained/non-trained), and diagnosis (HC/SCD) was used to investigate significant changes in FC. Results: We found an average increase in alpha-band FC over time, but the effect was different in each group (trained and non-trained). In the trained group (HC and SCD), we report a reduction in the increase in FC within temporo-parietal and temporo-occipital connections. In the trained SCD group, this reduction was stronger and showed a tentative correlation with improved performance in different cognitive tests. Conclusion: COGTR interventions could mitigate aberrant increases in FC in preclinical AD, promoting brain synchrony normalization in groups at a higher risk of developing dementia. ; Comunidad de Madrid ; Comisión Europea ; Depto. de Psicología Experimental, Procesos Cognitivos y Logopedia ; Depto. de Radiología, Rehabilitación y Fisioterapia ; Fac. de Psicología ; Fac. de Medicina ; FALSE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1387-2877 1875-8908 |
| Relation: | B2017/BMD-3760; 826421; https://hdl.handle.net/20.500.14352/100357; Suárez-Méndez, Isabel et al. ‘Cognitive Training Modulates Brain Hypersynchrony in a Population at Risk for Alzheimer’s Disease’. 1 Jan. 2022 : 1185 – 1199.; https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215406 |
| DOI: | 10.3233/JAD-215406 |
| الاتاحة: | https://hdl.handle.net/20.500.14352/100357 https://doi.org/10.3233/JAD-215406 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215406 |
| Rights: | Attribution-NonCommercial-ShareAlike 4.0 International ; http://creativecommons.org/licenses/by-nc-sa/4.0/ ; open access |
| رقم الانضمام: | edsbas.918ED7E9 |
| قاعدة البيانات: | BASE |
| تدمد: | 13872877 18758908 |
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| DOI: | 10.3233/JAD-215406 |