Academic Journal
The effects of sex-steroid administration on the pituitary–thyroid axis in transsexuals
| العنوان: | The effects of sex-steroid administration on the pituitary–thyroid axis in transsexuals |
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| المؤلفون: | Bisschop, Peter H, Toorians, Arno W, Endert, Erik, Wiersinga, Wilmar M, Gooren, Louis J, Fliers, Eric |
| المصدر: | European Journal of Endocrinology ; volume 155, issue 1, page 11-16 ; ISSN 0804-4643 1479-683X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism |
| الوصف: | Objective : Estrogen and androgen administration modulate the pituitary–thyroid axis through alterations in thyroid hormone-binding globulin (TBG) metabolism, but the effects of sex steroids on extrathyroidal thyroxine (T 4 ) to triiodothyronine (T 3 ) conversion in humans are unknown. Design and methods : We studied 36 male-to-female and 14 female-to-male euthyroid transsexuals at baseline and after 4 months of hormonal treatment. Male-to-female transsexuals were treated with cyproterone acetate (CA) 100 mg/day alone ( n =10) or in combination with either oral ethinyl estradiol (or-EE) 100 μg/day ( n =14) or transdermal 17β-estradiol (td-E) 100 μg twice a week ( n =12). Female-to-male transsexuals were treated with i.m. testosterone 250 mg twice a week. A t- test was used to test for differences within groups and ANOVAwith post hoc analysis to test for differences between the groups. Results : Or-EE increased TBG (100 ± 12%, P <.001) and testosterone decreased TBG (−14 ± 4%, P =0.01), but free T 4 did not change. Td-E and CA did not affect TBG concentrations. TSH was not different between groups at baseline or after treatment. CA decreased T 3 /T 4 ratios (−9 ± 3%, P =0.04), suggesting that T 4 to T 3 conversion was lower. Testosterone increased T 3 /T 4 ratios (30 ± 9%, P =0.02), which probably reflects higher T 4 to T 3 conversion. Conclusion : Oral but not transdermal estradiol increases TBG, whereas testosterone lowers TBG. Testosterone increases T 3 /T 4 ratios. Estradiol does not affect T 3 /T 4 ratios, irrespective of the route of administration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/eje.1.02192 |
| الاتاحة: | http://dx.doi.org/10.1530/eje.1.02192 https://eje.bioscientifica.com/view/journals/eje/155/1/1550011.xml |
| رقم الانضمام: | edsbas.91422D8F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/eje.1.02192 |
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