Academic Journal
FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated Diarylmethanones
| العنوان: | FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated Diarylmethanones |
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| المؤلفون: | Chan, Cheng-Lin, Lee, Shao-Chi, Lin, Pei-Shan, Tapales, Radyn Vanessa Phaz P., Li, Jia-Syuan, Lai, Chun-An, Lee, Jyh-Tsung, Li, Chien-Hung, Liao, Hsuan-Hung |
| المساهمون: | KAUST Catalysis Center (KCC), Physical Science and Engineering (PSE) Division, Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804201, Taiwan (R.O.C.), Department of International Ph.D. Program for Science, National Sun Yat-sen University, Kaohsiung 804201, Taiwan (R.O.C.), Department of Chemistry, National Chung Hsing University, Taichung 402202, Taiwan (R.O.C.), Department of Applied and Medicinal Chemistry, Kaohsiung Medical University, Kaohsiung 807378, Taiwan (R.O.C.) |
| بيانات النشر: | American Chemical Society (ACS) |
| سنة النشر: | 2024 |
| المجموعة: | King Abdullah University of Science and Technology: KAUST Repository |
| الوصف: | A mild, facile, and metal-free approach via the N-heterocyclic carbene-catalyzed SNAr reaction between aryl aldehydes with perfluoroarenes to obtain the coveted functional perfluorinated diarylmethanones is disclosed. This method accommodates a diverse substrate range and exhibits notable tolerance toward various functional groups. Our success in modifying biologically relevant molecules, crafting a fully fluorinated bioisosteric analogue of drug candidate D1, and highlighting the potential of these ketones as valuable electrolyte additives for lithium-ion batteries (LIBs) underscores the versatility of our methodology. ; This research received essential financial support through the National Science and Technology Council (NSTC 112-2636-M-110-003 and Yushan Young Scholar Program of the Ministry of Education of Taiwan. The authors express their gratitude to Dr. Daniel Kaiser (University of Vienna) for proofreading our manuscript. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| تدمد: | 1523-7060 1523-7052 |
| Relation: | Organic Letters; http://hdl.handle.net/10754/697635 |
| DOI: | 10.1021/acs.orglett.4c00677 |
| الاتاحة: | http://hdl.handle.net/10754/697635 https://doi.org/10.1021/acs.orglett.4c00677 |
| Rights: | Archived with thanks to Organic Letters under a Creative Commons license, details at: https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.9119B8B5 |
| قاعدة البيانات: | BASE |
| تدمد: | 15237060 15237052 |
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| DOI: | 10.1021/acs.orglett.4c00677 |