Academic Journal
MR Elastography of the Pancreas:Bowel Preparation and Repeatability Assessment in Pancreatic Cancer Patients and Healthy Controls
| العنوان: | MR Elastography of the Pancreas:Bowel Preparation and Repeatability Assessment in Pancreatic Cancer Patients and Healthy Controls |
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| المؤلفون: | Wassenaar, Nienke P. M., van Schelt, Anne-Sophie, Schrauben, Eric M., Kop, Marnix P. M., Nio, C. Yung, Wilmink, Johanna W., Besselink, Marc G. H., van Laarhoven, Hanneke W. M., Stoker, Jaap, Nederveen, Aart J., Runge, Jurgen H. |
| المصدر: | Wassenaar , N P M , van Schelt , A-S , Schrauben , E M , Kop , M P M , Nio , C Y , Wilmink , J W , Besselink , M G H , van Laarhoven , H W M , Stoker , J , Nederveen , A J & Runge , J H 2023 , ' MR Elastography of the Pancreas : Bowel Preparation and Repeatability Assessment in Pancreatic Cancer Patients and Healthy Controls ' , Journal of Magnetic Resonance Imaging . https://doi.org/10.1002/jmri.28918 |
| سنة النشر: | 2023 |
| الوصف: | Background: Pancreatic ductal adenocarcinoma (PDAC) stromal viscoelasticity can be measured using MR elastography (MRE). Bowel preparation regimens could affect MRE quality and knowledge on repeatability is crucial for clinical implementation. Purpose: To assess effects of four bowel preparation regimens on MRE quality and to evaluate repeatability and differentiate patients from healthy controls. Study Type: Prospective. Population: 15 controls (41 ± 16 years; 47% female), 16 PDAC patients (one excluded, 66 ± 12 years; 40% female) with 15 age-/sex-matched controls (65 ± 11 years; 40% female). Final sample size was 25 controls and 15 PDAC. Field Strength/Sequence: 3-T, spin-echo echo-planar-imaging, turbo spin-echo, and fast field echo gradient-echo. Assessment: Four different regimens were used: fasting; scopolaminebutyl; drinking 0.5 L water; combination of 0.5 L water and scopolaminebutyl. MRE signal-to-noise ratio (SNR) was compared between all regimens. MRE repeatability (test–retest) and differences in shear wave speed (SWS) and phase angle (ϕ) were assessed in PDAC and controls. Regions-of-interest were defined for tumor, nontumorous (n = 8) tissue in PDAC, and whole pancreas in controls. Two radiologists delineated tumors twice for evaluation of intraobserver and interobserver variability. Statistical Tests: Repeated measures analysis of variance, coefficients of variation (CoVs), Bland–Altman analysis, (un)paired t-test, Mann–Whitney U-test, and Wilcoxon signed-rank test. P-value<0.05 was considered statistically significant. Results: Preparation regimens did not significantly influence MRE-SNR. Therefore, the least burdensome preparation (fasting only) was continued. CoVs for tumor SWS were: intrasession (12.8%) and intersession (21.7%), and intraobserver (7.9%) and interobserver (10.3%) comparisons. For controls, CoVs were intrasession (4.6%) and intersession (6.4%). Average SWS for tumor, nontumor, and healthy tissue were: 1.74 ± 0.58, 1.38 ± 0.27, and 1.18 ± 0.16 m/sec (ϕ: 1.02 ± 0.17, 0.91 ± ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jmri.28918 |
| الاتاحة: | https://research.vumc.nl/en/publications/d35082b8-8c1e-4bf3-ae13-5f4f480a8dd3 https://doi.org/10.1002/jmri.28918 http://www.scopus.com/inward/record.url?scp=85165424073&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.90FF644 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jmri.28918 |
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