Academic Journal
Can clinicopathological factors improve the prediction of metastasis to nonsentinel lymph nodes in patients with breast cancer? ; ¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama?
| العنوان: | Can clinicopathological factors improve the prediction of metastasis to nonsentinel lymph nodes in patients with breast cancer? ; ¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama? |
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| المؤلفون: | García-Mejido, José A, Sánchez-Sevilla, Miguel, González-Martínez, Jesús, Fernández-Palacín, Ana, Sainz-Bueno, José A |
| سنة النشر: | 2022 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Amplificación de ácido nucleico/OSNA, CK19, Carcinoma breast cancer, Carcinoma cáncer de mama, Carga tumoral, Ganglio centinela/SLN, Nucleic acid amplification/OSNA, Sentinel lymph node/SLN, Tumor load CK19, Axilla, Breast Neoplasms, Female, Humans, Lymph Node Excision, Lymph Nodes, Lymphatic Metastasis, RNA, Messenger, Sentinel Lymph Node Biopsy |
| الوصف: | To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biopsies. 118 required a complete axillary lymph node dissection (ALNhD). About 35.6% (42/118) had metastases to a NSLN, and 64.4% (76/118) had no metastasis to a NSLN. The ROC curve of the total tumor load (TTL) presented an area under the curve (AUC) of 0.651 (95%; CI: 0.552-0.751). The 7294 copies of CK19 mRNA were established as the optimal cutoff point, with sensitivity: 93%, specificity: 63%, positive predictive value: 44%, and negative predictive value: 91%. By associating the clinicopathological parameters (multicentricity, pooled immunohistochemistry [IHC], and progesterone receptors), the AUC went up to 0.752 (95% CI: 0.663-0.841). Clinicopathological factors should be considered together with the total CK19 mRNA copy number (the TTL) of the SLNs to improve the predictive capacity of metastatic involvement of the NSLNs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2444-054X |
| Relation: | http://hdl.handle.net/10668/21791; https://www.cirugiaycirujanos.com/files/circir_22_90_4_473-480.pdf |
| DOI: | 10.24875/CIRU.21000148 |
| الاتاحة: | http://hdl.handle.net/10668/21791 https://doi.org/10.24875/CIRU.21000148 https://www.cirugiaycirujanos.com/files/circir_22_90_4_473-480.pdf |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; open access |
| رقم الانضمام: | edsbas.90F95EDD |
| قاعدة البيانات: | BASE |
| تدمد: | 2444054X |
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| DOI: | 10.24875/CIRU.21000148 |