Academic Journal
The effect of sertindole on QTD and TPTE
| العنوان: | The effect of sertindole on QTD and TPTE |
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| المؤلفون: | Nielsen, Jimmi, Andersen, M P, Graff, C, Kanters, J K, Hardahl, T, Dybbro, J, Struijk, J J, Meyer, J M, Toft, E |
| المصدر: | Nielsen , J , Andersen , M P , Graff , C , Kanters , J K , Hardahl , T , Dybbro , J , Struijk , J J , Meyer , J M & Toft , E 2010 , ' The effect of sertindole on QTD and TPTE ' , Acta Psychiatrica Scandinavica , vol. 121 , no. 5 , pp. 385-8 . https://doi.org/10.1111/j.1600-0447.2009.01534.x |
| سنة النشر: | 2010 |
| المجموعة: | Aarhus University: Research |
| الوصف: | Udgivelsesdato: 2010 ; Nielsen J, Andersen MP, Graff C, Kanters JK, Hardahl T, Dybbro J, Struijk JJ, Meyer JM, Toft E. The effect of sertindole on QTD and TPTE. Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 +/- 22 ms, mean QTcF prolongation during sertindole treatment was 20 +/- 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 +/- 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 +/- 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1600-0447.2009.01534.x |
| الاتاحة: | https://pure.au.dk/portal/da/publications/the-effect-of-sertindole-on-qtd-and-tpte(d0c0aa70-2dcc-11df-9806-000ea68e967b).html https://doi.org/10.1111/j.1600-0447.2009.01534.x |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.90F3AF5D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1600-0447.2009.01534.x |
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