Academic Journal
Recent knowledge of NFATc4 in oncogenesis and cancer prognosis
| العنوان: | Recent knowledge of NFATc4 in oncogenesis and cancer prognosis |
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| المؤلفون: | Zhong, Qiu-Hua, Zha, Si-Wei, Lau, Andy T. Y., Xu, Yan-Ming |
| المساهمون: | National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, “Thousand, Hundred, and Ten” Project of the Department of Education of Guangdong Province of China, Basic and Applied Research Major Projects of Guangdong Province of China, “Yang Fan” Project of Guangdong Province of China, Shantou Medical Health Science and Technology Plan |
| المصدر: | Cancer Cell International ; volume 22, issue 1 ; ISSN 1475-2867 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca 2+ /calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breast, ovary, cervix, skin, liver, pancreas, as well as glioma, primary myelofibrosis and acute myelocytic leukemia). In this review, we cover the latest knowledge on NFATc4 expression pattern, post-translational modification, epigenetic regulation, transcriptional activity regulation and its downstream targets. Furthermore, we perform database analysis to reveal the prognostic value of NFATc4 in various cancers and discuss the current unexplored areas of NFATc4 research. All in all, the result from these studies strongly suggest that NFATc4 has the potential as a molecular therapeutic target in multiple human cancer types. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12935-022-02619-6 |
| DOI: | 10.1186/s12935-022-02619-6.pdf |
| DOI: | 10.1186/s12935-022-02619-6/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12935-022-02619-6 https://link.springer.com/content/pdf/10.1186/s12935-022-02619-6.pdf https://link.springer.com/article/10.1186/s12935-022-02619-6/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.90DA8E80 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12935-022-02619-6 |
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