Academic Journal
Effect of maternal sleep on embryonic development
| العنوان: | Effect of maternal sleep on embryonic development |
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| المؤلفون: | Vietheer, Alexander, Kiserud, Torvid, Haaland, Øystein Ariansen, Lie, Rolv Terje, Kessler, Jörg |
| المساهمون: | Western Norway Health Trust, Norway, University of Bergen |
| المصدر: | Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | The concept of developmental origin of health and disease has ignited a search for mechanisms and health factors influencing normal intrauterine development. Sleep is a basic health factor with substantial individual variation, but its implication for early prenatal development remains unclear. During the embryonic period, the yolk sac is involved in embryonic nutrition, growth, hematopoiesis, and likely in fetal programming. Maternal body measures seem to influence its size in human female embryos. In this prospective, longitudinal observational study of 190 healthy women recruited before natural conception, we assessed the effect of prepregnant sleep duration (actigraphy) on the fetal crown-rump-length (CRL) and yolk sac size (ultrasound). All women gave birth to a live child. The prepregnancy daily sleep duration had an effect on the male yolk sac and CRL at the earliest measurement only (7 weeks). I.e., the yolk sac diameter decreased with increasing sleep duration (0.22 mm·h −1 d −1 , 95%CI [0.35-0.09], P < 0.01 ), and CRL decreased (0.92 mm·h −1 d −1 , 95%CI [1.77-0.08], P = 0.03). Since there was no association at the second measurement (10 weeks), and in the group of female fetuses at any measure point, we suggest a sex- and time-dependent embryonic adaptation to sleep generated differences in the intrauterine environment in normal pregnancies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-022-21516-6 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-022-21516-6 https://www.nature.com/articles/s41598-022-21516-6.pdf https://www.nature.com/articles/s41598-022-21516-6 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.90993FA7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-022-21516-6 |
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