Academic Journal
Dual Host-Intracellular Parasite Transcriptome of Enucleated Cells Hosting Leishmania amazonensis : Control of Half-Life of Host Cell Transcripts by the Parasite
| العنوان: | Dual Host-Intracellular Parasite Transcriptome of Enucleated Cells Hosting Leishmania amazonensis : Control of Half-Life of Host Cell Transcripts by the Parasite |
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| المؤلفون: | Orikaza, Cristina M., Pessoa, Carina C., Paladino, Fernanda V., Florentino, Pilar T. V., Barbiéri, Clara L., Goto, Hiro, Ramos-Sanchez, Eduardo Milton, Franco da Silveira, José, Rabinovitch, Michel, Mortara, Renato A., Real, Fernando |
| المساهمون: | Herbert, De’Broski R., Fundação de Amparo à Pesquisa do Estado de São Paulo |
| المصدر: | Infection and Immunity ; volume 88, issue 11 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2020 |
| الوصف: | Enucleated cells or cytoplasts (cells whose nucleus is removed in vitro ) represent an unexplored biological model for intracellular infection studies due to the abrupt interruption of nuclear processing and new RNA synthesis by the host cell in response to pathogen entry. Using enucleated fibroblasts hosting the protozoan parasite Leishmania amazonensis , we demonstrate that parasite multiplication and biogenesis of large parasitophorous vacuoles in which parasites multiply are independent of the host cell nucleus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.00261-20 |
| DOI: | 10.1128/IAI.00261-20 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.00261-20 https://journals.asm.org/doi/pdf/10.1128/IAI.00261-20 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.9095901B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.00261-20 |
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