Academic Journal
Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
| العنوان: | Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy |
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| المؤلفون: | Zou, Yuheng, Zhang, Hongying, Bi, Feng, Tang, Qiulin, Xu, Huanji |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Frontiers in Oncology ; volume 12 ; ISSN 2234-943X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fonc.2022.938502 |
| DOI: | 10.3389/fonc.2022.938502/full |
| الاتاحة: | http://dx.doi.org/10.3389/fonc.2022.938502 https://www.frontiersin.org/articles/10.3389/fonc.2022.938502/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.90942CD2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.938502 |
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