Academic Journal
Potential application of [18F]AlF-PSMA-11 PET/CT in radioiodine refractory thyroid carcinoma
| العنوان: | Potential application of [18F]AlF-PSMA-11 PET/CT in radioiodine refractory thyroid carcinoma |
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| المؤلفون: | Van den Broeck, Bliede, Debacker, Jens, Bauters, Wouter, Creytens, David, Ferdinande, Liesbeth, Huvenne, Wouter, Lapauw, Bruno, Schelfhout, Vanessa, Van Laeken, Nick, Verroken, Charlotte |
| المصدر: | EJNMMI RESEARCH ; ISSN: 2191-219X |
| سنة النشر: | 2024 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Thyroid carcinoma, Radio-iodine refractory thyroid carcinoma, PET/CT, PSMA-11, MEMBRANE ANTIGEN-EXPRESSION, VESSEL CO-OPTION, PSMA EXPRESSION, ASSOCIATION GUIDELINES, PROSTATE-CANCER, METASTASES, MANAGEMENT, RESISTANCE, PAPILLARY, ADENOMA |
| الوصف: | Background Patients diagnosed with radioiodine refractory (RAI-R) thyroid carcinoma (TC) have a significantly worse prognosis than patients with radiosensitive TC. These refractory malignancies are often dedifferentiated, hindering the effectiveness of iodine-based imaging. Additionally, the role of metabolic imaging using [F-18]FDG PET/CT is also limited in these cases, making adequate staging of RAI-R TC challenging. Recent case series have shown promising results regarding the role of the prostate-specific membrane antigen (PSMA) in TC. In this study we explored the value of [F-18]AlF-PSMA-11 PET/CT in RAI-R TC. Methods In this phase II study, lesions detected on [F-18]AlF-PSMA-11 PET were compared to findings from [18F]FDG PET/CT. Additionally, the serologic soluble prostate-specific membrane antigen (sPSMA) was measured using ELISA. PSMA-expression on tumor tissue in any available resection specimens was analysed with an immunostainer. Results Eight patients were included, with a total of 39 identified lesions based on PET imaging. [18F]AlF-PSMA-11 PET identified 30 of 39 lesions, and [F-18]FDG PET identified 33 lesions, leading to a detection rate of 76.9% and 84.6%, respectively. Interestingly, while nine lesions were solely visualized on [F-18]FDG, six were uniquely seen on [F-18]AlF-PSMA-11 PET. While sPSMA was immeasurable in all female patients, no correlation was found between sPSMA in male patients and disease-related factors. In five out of eight patients immunohistology showed PSMA expression on the primary tumor. Conclusions Although not all lesions could be visualized, [F-18]PSMA-11 PET identified multiple lesions imperceptible on [F-18]FDG PET. These results display the potential additional diagnostic role of PSMA-targeted imaging in patients with RAI-R TC.Trial registration number No. EudraCT 2021-000456-19. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/01J7RG0PDHD1W4P92AJ7KV5CWX; https://biblio.ugent.be/publication/01J7RG0PDHD1W4P92AJ7KV5CWX/file/01J7RG9GSWAS1HA32YQXVJBVHS |
| DOI: | 10.1186/s13550-024-01148-9 |
| الاتاحة: | https://biblio.ugent.be/publication/01J7RG0PDHD1W4P92AJ7KV5CWX http://hdl.handle.net/1854/LU-01J7RG0PDHD1W4P92AJ7KV5CWX https://doi.org/10.1186/s13550-024-01148-9 https://biblio.ugent.be/publication/01J7RG0PDHD1W4P92AJ7KV5CWX/file/01J7RG9GSWAS1HA32YQXVJBVHS |
| Rights: | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License (CC BY-NC-ND 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.904D06A3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13550-024-01148-9 |
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