Academic Journal
A new 4D trajectory-based approach unveils abnormal LV revolution dynamics in hypertrophic cardiomyopathy
| العنوان: | A new 4D trajectory-based approach unveils abnormal LV revolution dynamics in hypertrophic cardiomyopathy |
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| المؤلفون: | MADEO, ANDREA, PIRAS, PAOLO, F. Re, S. Gabriele, NARDINOCCHI, Paola, L. Teresi, TORROMEO, Concetta, C. Chialastri, SCHIARITI, Michele Salvatore Maria, GIURA, GELTRUDE, EVANGELISTA, Antonietta, T. Dominici, V. Varano, E. Zachara, PUDDU, Paolo Emilio |
| المساهمون: | Madeo, Andrea, Piras, Paolo, F., Re, S., Gabriele, Nardinocchi, Paola, L., Teresi, Torromeo, Concetta, C., Chialastri, Schiariti, Michele Salvatore Maria, Giura, Geltrude, Evangelista, Antonietta, T., Dominici, V., Varano, E., Zachara, Puddu, Paolo Emilio |
| بيانات النشر: | Public Library of Science San Francisco, CA |
| سنة النشر: | 2015 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | left ventricle, morphometry, hypertrophic cardiomyopathy |
| الوصف: | The assessment of left ventricular shape changes during cardiac revolution may be a new step in clinical cardiology to ease early diagnosis and treatment. To quantify these changes, only point registration was adopted and neither Generalized Procrustes Analysis nor Princi- pal Component Analysis were applied as we did previously to study a group of healthy sub- jects. Here, we extend to patients affected by hypertrophic cardiomyopathy the original approach and preliminarily include genotype positive/phenotype negative individuals to ex- plore the potential that incumbent pathology might also be detected. Using 3D Speckle Tracking Echocardiography, we recorded left ventricular shape of 48 healthy subjects, 24 patients affected by hypertrophic cardiomyopathy and 3 genotype positive/phenotype nega- tive individuals. We then applied Generalized Procrustes Analysis and Principal Compo- nent Analysis and inter-individual differences were cleaned by Parallel Transport performed on the tangent space, along the horizontal geodesic, between the per-subject consensuses and the grand mean. Endocardial and epicardial layers were evaluated separately, different from many ecocardiographic applications. Under a common Principal Component Analysis, we then evaluated left ventricle morphological changes (at both layers) explained by first Principal Component scores. Trajectories’ shape and orientation were investigated and contrasted. Logistic regression and Receiver Operating Characteristic curves were used to compare these morphometric indicators with traditional 3D Speckle Tracking Echocardiog- raphy global parameters. Geometric morphometrics indicators performed better than 3D Speckle Tracking Echocardiography global parameters in recognizing pathology both in systole and diastole. Genotype positive/phenotype negative individuals clustered with patients affected by hypertrophic cardiomyopathy during diastole, suggesting that incum- bent pathology may indeed be foreseen by these methods. Left ventricle deformation in pa- ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25875818; info:eu-repo/semantics/altIdentifier/wos/WOS:000352845100069; volume:10; issue:4; numberofpages:33; journal:PLOS ONE; http://hdl.handle.net/11573/780392; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84928922750; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122376 |
| DOI: | 10.1371/journal.pone.0122376 |
| الاتاحة: | http://hdl.handle.net/11573/780392 https://doi.org/10.1371/journal.pone.0122376 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122376 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8FF53B4A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0122376 |
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