Review
Sarcoma treatment in the era of molecular medicine
| العنوان: | Sarcoma treatment in the era of molecular medicine |
|---|---|
| المؤلفون: | Grünewald, Thomas G. P., Alonso, Marta, Avnet, Sofia, Banito, Ana, Burdach, Stefan, Cidre-Aranaz, Florencia, Di Pompo, Gemma, Distel, Martin, Dorado-Garcia, Heathcliff, Garcia-Castro, Javier, Gonzalez-Gonzalez, Laura, Grigoriadis, Agamemnon E., Kasan, Merve, Koelsche, Christian, Krumbholz, Manuela, Lecanda, Fernando, Lemma, Silvia, Longo, Dario L., Madrigal-Esquivel, Claudia, Morales-Molina, Alvaro, Musa, Julian, Ohmura, Shunya, Ory, Benjamin, Pereira-Silva, Miguel, Perut, Francesca, Rodriguez, Rene, Seeling, Carolin, Al Shaaili, Nada, Shaabani, Shabnam, Shiavone, Kristina, Sinha, Snehadri, Tomazou, Eleni M., Trautmann, Marcel, Vela, Maria, Versleijen-Jonkers, Yvonne M. H., Visgauss, Julia, Zalacain, Marta, Schober, Sebastian J., Lissat, Andrej, English, William R., Baldini, Nicola, Heymann, Dominique |
| المساهمون: | Department of Oral and Maxillofacial Diseases, University of Helsinki, HUS Helsinki and Uusimaa Hospital District |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | bone sarcoma, molecular diagnostics, molecular medicine, soft tissue sarcoma, targeted therapy, SOFT-TISSUE SARCOMA, CIRCULATING TUMOR-CELLS, CANCER STEM-CELLS, CONDITIONALLY REPLICATIVE ADENOVIRUS, GASTROINTESTINAL STROMAL TUMORS, PATIENT-DERIVED XENOGRAFTS, ENDOTHELIAL GROWTH-FACTOR, EARLY METABOLIC-RESPONSE, LIMB-SALVAGE TREATMENT, INFILTRATING T-CELLS, Cancers |
| الوصف: | Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma. ; Peer reviewed |
| نوع الوثيقة: | review |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Grünewald , T G P , Alonso , M , Avnet , S , Banito , A , Burdach , S , Cidre-Aranaz , F , Di Pompo , G , Distel , M , Dorado-Garcia , H , Garcia-Castro , J , Gonzalez-Gonzalez , L , Grigoriadis , A E , Kasan , M , Koelsche , C , Krumbholz , M , Lecanda , F , Lemma , S , Longo , D L , Madrigal-Esquivel , C , Morales-Molina , A , Musa , J , Ohmura , S , Ory , B , Pereira-Silva , M , Perut , F , Rodriguez , R , Seeling , C , Al Shaaili , N , Shaabani , S , Shiavone , K , Sinha , S , Tomazou , E M , Trautmann , M , Vela , M , Versleijen-Jonkers , Y M H , Visgauss , J , Zalacain , M , Schober , S J , Lissat , A , English , W R , Baldini , N & Heymann , D 2020 , ' Sarcoma treatment in the era of molecular medicine ' , EMBO molecular medicine , vol. 12 , no. 11 , 11131 . https://doi.org/10.15252/emmm.201911131; ORCID: /0000-0002-8080-5305/work/88209793; http://hdl.handle.net/10138/325961; 75fdd78a-247a-49d9-8005-d8aa40f873b9; 000578667600001 |
| الاتاحة: | http://hdl.handle.net/10138/325961 |
| Rights: | info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: | edsbas.8FEED0CE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |