Academic Journal
Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and anti-inflammatory activities
| العنوان: | Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and anti-inflammatory activities |
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| المؤلفون: | de Cássia dos Santos, Raquel, Bonamin, Flavia, Périco, Larissa Lucena, Rodrigues, Vinícius Peixoto, Zanatta, Ana Caroline, Rodrigues, Clenilson Martins, Sannomiya, Miriam, dos Santos Ramos, Matheus Aparecido, Bonifácio, Bruna Vidal, Bauab, Taís Maria, Tamashiro, Jorge, da Rocha, Lúcia Regina Machado, Vilegas, Wagner, Hiruma-Lima, Clelia Akiko |
| المساهمون: | Universidade Estadual Paulista (UNESP) |
| سنة النشر: | 2019 |
| المجموعة: | Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: | Anti-inflammatory activity, Byrsonima intermedia A. Juss, Healing effect, Peptic ulcer |
| الوصف: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; CNPq: 305570/2012-9 ; Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acid-induced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1112-1123 |
| اللغة: | English |
| تدمد: | 1950-6007 0753-3322 |
| Relation: | Biomedicine and Pharmacotherapy; http://dx.doi.org/10.1016/j.biopha.2018.12.132; Biomedicine and Pharmacotherapy, v. 111, p. 1112-1123.; http://hdl.handle.net/11449/190029; 2-s2.0-85059802015; 3814504901386844; orcid:0000-0002-8645-3777 |
| DOI: | 10.1016/j.biopha.2018.12.132 |
| الاتاحة: | http://hdl.handle.net/11449/190029 https://doi.org/10.1016/j.biopha.2018.12.132 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.8FE9A802 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19506007 07533322 |
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| DOI: | 10.1016/j.biopha.2018.12.132 |