Academic Journal
Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features
| العنوان: | Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features |
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| المؤلفون: | Zhang, L., Verwer, R.W.H, Zhao, J., Huitinga, I., Lucassen, P.J., Swaab, D.F. |
| المصدر: | Zhang , L , Verwer , R W H , Zhao , J , Huitinga , I , Lucassen , P J & Swaab , D F 2021 , ' Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features ' , Journal of Affective Disorders , vol. 295 , pp. 893-903 . https://doi.org/10.1016/j.jad.2021.08.098 |
| سنة النشر: | 2021 |
| المجموعة: | Universiteit van Amsterdam: Digital Academic Repository (UvA DARE) |
| الوصف: | BACKGROUND: To establish whether major depressive disorder (MDD), suicidal behaviors and psychotic features contribute to glial alterations in the human prefrontal cortex. MATERIALS AND METHODS: We compared mRNA expression using real-time qPCR of 17 glia related genes in the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) between 24 patients with MDD and 12 well-matched controls without psychiatric or neurological diseases. The MDD group was subdivided into i) MDD who died of suicide (MDD-S) or natural causes (MDD-NS) and ii) MDD with or without psychotic features (MDD-P and MDD-NP). The results were followed up with confounder factor analysis. RESULTS: Astrocyte gene aldehyde dehydrogenase-1 L1 (ALDH1L1) showed an increased expression in the DLPFC of MDD-NS and the ACC of MDD-NP. S100 calcium-binding protein B (S100B) was upregulated in the DLPFC of MDD compared to the controls. Microglial markers CD11B and purinergic receptor 12 (P2RY12) both showed decreased expression in the ACC of MDD-NS. CD68 was increased in the DLPFC of MDD in both, MDD-S and MDD-P, compared to the controls. In addition, there was increased translocator protein (TSPO) expression in the DLPFC of MDD, especially MDD-NS. In the ACC, this gene had a lower expression in MDD-P than in MDD-NP. Myelin basic protein (MBP) mRNA in the DLPFC increased in MDD, in relation to psychotic features, but not to suicide. LIMITATIONS: Sample volumes are relatively small. CONCLUSIONS: Different glial functions in MDD were related to specific brain area, suicide or psychotic features. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.jad.2021.08.098 |
| الاتاحة: | https://dare.uva.nl/personal/pure/en/publications/changes-in-glial-gene-expression-in-the-prefrontal-cortex-in-relation-to-major-depressive-disorder-suicide-and-psychotic-features(b2742188-a4b0-490e-b880-b5c18bfd5945).html https://doi.org/10.1016/j.jad.2021.08.098 https://hdl.handle.net/11245.1/b2742188-a4b0-490e-b880-b5c18bfd5945 https://pure.uva.nl/ws/files/67378841/1_s2.0_S0165032721009034_main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8FCF94C3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jad.2021.08.098 |
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