Academic Journal
The expansion of activated naive DNA autoreactive B cells and its association with disease activity in systemic lupus erythematosus patients
| العنوان: | The expansion of activated naive DNA autoreactive B cells and its association with disease activity in systemic lupus erythematosus patients |
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| المؤلفون: | Kittikorn Wangriatisak, Chokchai Thanadetsuntorn, Thamonwan Krittayapoositpot, Chaniya Leepiyasakulchai, Thanitta Suangtamai, Pintip Ngamjanyaporn, Ladawan Khowawisetsut, Prasong Khaenam, Chavachol Setthaudom, Prapaporn Pisitkun, Patchanee Chootong |
| المصدر: | Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | BMC |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Systemic lupus erythematosus, Activated naïve B cell, DNA autoreactive B cell, Disease activity, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Background Autoreactive B cells are well recognized as key participants in the pathogenesis of systemic lupus erythematosus (SLE). However, elucidating the particular subset of B cells in producing anti-dsDNA antibodies is limited due to their B cell heterogeneity. This study aimed to identify peripheral B cell subpopulations that display autoreactivity to DNA and contribute to lupus pathogenesis. Methods Flow cytometry was used to detect total B cell subsets (n = 20) and DNA autoreactive B cells (n = 15) in SLE patients’ peripheral blood. Clinical disease activities were assessed in SLE patients using modified SLEDAI-2 K and used for correlation analyses with expanded B cell subsets and DNA autoreactive B cells. Results The increases of circulating double negative 2 (DN2) and activated naïve (aNAV) B cells were significantly observed in SLE patients. Expanded B cell subsets and DNA autoreactive B cells represented a high proportion of aNAV B cells with overexpression of CD69 and CD86. The frequencies of aNAV B cells in total B cell populations were significantly correlated with modified SLEDAI-2 K scores. Further analysis showed that expansion of aNAV DNA autoreactive B cells was more related to disease activity and serum anti-dsDNA antibody levels than to total aNAV B cells. Conclusion Our study demonstrated an expansion of aNAV B cells in SLE patients. The association between the frequency of aNAV B cells and disease activity patients suggested that these expanded B cells may play a role in SLE pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1478-6362 |
| Relation: | https://doi.org/10.1186/s13075-021-02557-0; https://doaj.org/toc/1478-6362; https://doaj.org/article/7ac98c423e474c989818eed8dc57fa15 |
| DOI: | 10.1186/s13075-021-02557-0 |
| الاتاحة: | https://doi.org/10.1186/s13075-021-02557-0 https://doaj.org/article/7ac98c423e474c989818eed8dc57fa15 |
| رقم الانضمام: | edsbas.8F7C44AF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14786362 |
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| DOI: | 10.1186/s13075-021-02557-0 |