Academic Journal
Can Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study
| العنوان: | Can Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study |
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| المؤلفون: | Deye, Nicolas, Le Gouge, Amelie, François, Bruno, Chenevier-Gobeaux, Camille, Daix, Thomas, Merdji, Hamid, Cariou, Alain, Dequin, Pierre-François, Guitton, Christophe, Mégarbane, Bruno, Callebert, Jacques, Giraudeau, Bruno, Mebazaa, Alexandre, Vodovar, Nicolas |
| المساهمون: | Hôpital Lariboisière-Fernand-Widal APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Limoges, Hôpital Cochin AP-HP, Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Réanimation Polyvalente CHU Limoges, Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Centre d’Investigation Clinique Tours CIC 1415 (CIC), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Réanimation médico-chirurgicale CH Le Mans, Centre Hospitalier Le Mans (CH Le Mans), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S 1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Réanimation Médicale et Toxicologique Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal APHP, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris |
| المصدر: | ISSN: 2639-8028 ; Critical Care Explorations ; https://hal.science/hal-04674146 ; Critical Care Explorations, 2024, 6 (7), pp.e1104. ⟨10.1097/cce.0000000000001104⟩. |
| بيانات النشر: | HAL CCSD Wolters Kluwer Health |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | C-reactive protein/procalcitonin, biomarker, cardiac arrest, chemokine/interleukin, ventilator-assisted pneumonia, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Importance: Ventilator-associated pneumonia (VAP) frequently occurs in patients with cardiac arrest. Diagnosis of VAP after cardiac arrest remains challenging, while the use of current biomarkers such as C-reactive protein (CRP) or procalcitonin (PCT) is debated.Objectives: To evaluate biomarkers' impact in helping VAP diagnosis after cardiac arrest.Design setting and participants: This is a prospective ancillary study of the randomized, multicenter, double-blind placebo-controlled ANtibiotherapy during Therapeutic HypothermiA to pRevenT Infectious Complications (ANTHARTIC) trial evaluating the impact of antibiotic prophylaxis to prevent VAP in out-of-hospital patients with cardiac arrest secondary to shockable rhythm and treated with therapeutic hypothermia. An adjudication committee blindly evaluated VAP according to predefined clinical, radiologic, and microbiological criteria. All patients with available biomarker(s), sample(s), and consent approval were included.Main outcomes and measures: The main endpoint was to evaluate the ability of biomarkers to correctly diagnose and predict VAP within 48 hours after sampling. The secondary endpoint was to study the combination of two biomarkers in discriminating VAP. Blood samples were collected at baseline on day 3. Routine and exploratory panel of inflammatory biomarkers measurements were blindly performed. Analyses were adjusted on the randomization group.Results: Among 161 patients of the ANTHARTIC trial with available biological sample(s), patients with VAP (n = 33) had higher body mass index and Acute Physiology and Chronic Health Evaluation II score, more unwitnessed cardiac arrest, more catecholamines, and experienced more prolonged therapeutic hypothermia duration than patients without VAP (n = 121). In univariate analyses, biomarkers significantly associated with VAP and showing an area under the curve (AUC) greater than 0.70 were CRP (AUC = 0.76), interleukin (IL) 17A and 17C (IL17C) (0.74), macrophage colony-stimulating factor 1 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38957212; PUBMED: 38957212; PUBMEDCENTRAL: PMC11219183 |
| DOI: | 10.1097/cce.0000000000001104 |
| الاتاحة: | https://hal.science/hal-04674146 https://hal.science/hal-04674146v1/document https://hal.science/hal-04674146v1/file/Deye.pdf https://doi.org/10.1097/cce.0000000000001104 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8F6442D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/cce.0000000000001104 |
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