Academic Journal
Ground glass hepatocytes contain pre‐S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection
| العنوان: | Ground glass hepatocytes contain pre‐S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection |
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| المؤلفون: | Su, Ih‐Jen, Wang, Hui‐Ching, Wu, Han‐Chieh, Huang, Wen‐Ya |
| المصدر: | Journal of Gastroenterology and Hepatology ; volume 23, issue 8pt1, page 1169-1174 ; ISSN 0815-9319 1440-1746 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2008 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The discovery of “ground glass” hepatocytes (GGH) that contain hepatitis B virus (HBV) surface antigens by Hadziyannis and Popper in 1973 represents a historical landmark in the pathology of chronic HBV infection. Different types of GGH have been correlated to the expression patterns of surface/core antigens and the stages of virus replication. The original two types (designated types I & II) of GGH were found to contain specific pre‐S mutants with deletions over either pre‐S1 or pre‐S2 regions, respectively. Type II GGH consistently harbor pre‐S2 deletion mutants, which can escape from immune attack and grow preferentially to form clusters. Both types of pre‐S mutants can induce endoplasmic reticulum (ER) stress and oxidative DNA damage. The pre‐S2 mutants, albeit inducing a weaker level of ER stress signals, could additionally initiate ER stress‐independent retinoblastoma/adenovirus E2 promoter binding factor/cyclin A signaling through their interaction with c‐Jun activation domain binding protein 1 to degrade p27, illustrating the growth advantage of type II GGH. The combined effects of genomic instability and the proliferation of hepatocytes harboring pre‐S mutants could potentially lead to hepatocarcinogenesis over the decades of chronic HBV infection. The presence of pre‐S mutants in sera was reported to carry a high risk of developing hepatocellular carcinoma (HCC). Furthermore, transgenic mice harboring pre‐S2 mutant plasmids have been shown to develop a dysplastic change of hepatocytes and HCC. Therefore, in addition to being a histological marker of chronic HBV infection, GGH, particularly type II GGH, may represent the preneoplastic lesions of HBV‐related HCC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1440-1746.2008.05348.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1440-1746.2008.05348.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1746.2008.05348.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1746.2008.05348.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.8F601C8C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1440-1746.2008.05348.x |
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