Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial

التفاصيل البيبلوغرافية
العنوان:	Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial
المؤلفون:	Cook, Darrel A., Krajden, Mel, Brentnall, Adam R., Gondara, Lovedeep, Chan, Tracy, Law, Jennifer H., Smith, Laurie W., van Niekerk, Dirk J., Ogilvie, Gina S., Coldman, Andrew J., Warman, Rhian, Reuter, Caroline, Cuzick, Jack, Lorincz, Attila T.
المساهمون:	Canadian Institutes of Health Research, Cancer Research UK
المصدر:	International Journal of Cancer ; volume 144, issue 10, page 2587-2595 ; ISSN 0020-7136 1097-0215
بيانات النشر:	Wiley
سنة النشر:	2018
المجموعة:	Wiley Online Library (Open Access Articles via Crossref)
الوصف:	Human papillomavirus (HPV)‐based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. We conducted a blinded case–control study within the HPV FOCAL randomized cervical cancer screening trial of women aged 25–65 to examine whether baseline methylation testing using the S5 classifier provided triage performance similar to an algorithm relying on cytology and HPV genotyping. Groups were randomly selected from women with known HPV/cytology results and pathology outcomes. Group 1: 104 HPV positive (HPV+), abnormal cytology (54 CIN2/3; 50
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1002/ijc.31976
الاتاحة:	http://dx.doi.org/10.1002/ijc.31976 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.31976 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.31976 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.31976
Rights:	http://creativecommons.org/licenses/by/4.0/
رقم الانضمام:	edsbas.8F45A217
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1002/ijc.31976