Academic Journal
Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke
| العنوان: | Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke |
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| المؤلفون: | Juan Marta-Enguita, Manuel Navarro-Oviedo, Idoia Rubio-Baines, Nuria Aymerich, Maria Herrera, Beatriz Zandio, Sergio Mayor, Jose-Antonio Rodriguez, Jose-Antonio Páramo, Estefania Toledo, Maite Mendioroz, Roberto Muñoz, Josune Orbe |
| المصدر: | Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: | BMC |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Calprotectin, Mortality, Stroke, S100a9 protein, Biomarker, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein in the regulation of inflammation and thrombosis. The purpose of this study is to evaluate the association of circulating calprotectin with other inflammatory biomarkers and AIS prognosis, as well as the calprotectin content in stroke thrombi. Methods Among the 748 patients treated at a comprehensive stroke center between 2015 and 2017, 413 patients with confirmed acute ischemic injury were prospectively evaluated. Patients with systemic inflammation or infection at onset were excluded. Plasma calprotectin was measured by ELISA in blood samples of AIS patients within the first 24 h. Univariate and multivariate logistic regression models were performed to evaluate its association with mortality and functional independence (FI) at 3 months (defined as modified Rankin Scale < 3) and hemorrhagic transformation (HT) after ischemic stroke. Further, S100A9 was localized by immunostaining in stroke thrombi (n = 44). Results Higher calprotectin levels were associated with 3-month mortality, HT, and lower 3-month FI. After adjusting for potential confounders, plasma calprotectin remained associated with 3-month mortality [OR (95% CI) 2.31 (1.13–4.73)]. Patients with calprotectin ≥ 2.26 μg/mL were 4 times more likely to die [OR 4.34 (1.95–9.67)]. Addition of calprotectin to clinical variables led to significant improvement in the discrimination capacity of the model [0.91 (0.87–0.95) vs 0.89 (0.85–0.93); p < 0.05]. A multimarker approach demonstrated that patients with increased calprotectin, CRP, and NLR had the poorest outcome with a mortality rate of 42.3% during follow-up. S100A9 protein, as part of the heterodimer calprotectin, was present in all thrombi retrieved from AIS patients. Mean S100A9 content was 3.5% and tended to be higher in patients who died (p = 0.09). Moreover, it positively correlated with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1742-2094 |
| Relation: | https://doi.org/10.1186/s12974-020-02047-1; https://doaj.org/toc/1742-2094; https://doaj.org/article/486592091cd14972ba5ced10e3cfb400 |
| DOI: | 10.1186/s12974-020-02047-1 |
| الاتاحة: | https://doi.org/10.1186/s12974-020-02047-1 https://doaj.org/article/486592091cd14972ba5ced10e3cfb400 |
| رقم الانضمام: | edsbas.8F44AEFD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17422094 |
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| DOI: | 10.1186/s12974-020-02047-1 |