Academic Journal
Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy
| العنوان: | Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy |
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| المؤلفون: | Wang, You-Yuan, Zhen, Cheng, Hu, Wei, Huang, Hui-Huang, Li, Yan-Jun, Zhou, Ming-Ju, Li, Jing, Fu, Yu-Long, Zhang, Peng, Li, Xiao-Yu, Yang, Tao, Song, Jin-Wen, Fan, Xing, Zou, Jun, Meng, Si-Run, Qin, Ya-Qin, Jiao, Yan-Mei, Xu, Ruonan, Zhang, Ji-Yuan, Zhou, Chun-Bao, Yuan, Jin-Hong, Huang, Lei, Shi, Ming, Cheng, Liang, Wang, Fu-Sheng, Zhang, Chao |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Communications Biology ; volume 6, issue 1 ; ISSN 2399-3642 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic alterations. However, it is unclear whether these changes affect the anti-HIV function of CD8 + T cells. Here, we show that PLWH exhibit higher levels of plasma glutamate than healthy controls. In PLWH, glutamate levels positively correlate with HIV-1 reservoir and negatively correlate with the anti-HIV function of CD8 + T cells. Single-cell metabolic modeling reveals glutamate metabolism is surprisingly robust in virtual memory CD8 + T cells (TVM). We further confirmed that glutamate inhibits TVM cells function via the mTORC1 pathway in vitro. Our findings reveal an association between metabolic plasticity and CD8 + T cell-mediated HIV control, suggesting that glutamate metabolism can be exploited as a therapeutic target for the reversion of anti-HIV CD8 + T cell function in PLWH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s42003-023-04975-z |
| الاتاحة: | http://dx.doi.org/10.1038/s42003-023-04975-z https://www.nature.com/articles/s42003-023-04975-z.pdf https://www.nature.com/articles/s42003-023-04975-z |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.8ED7E0DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s42003-023-04975-z |
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