Academic Journal
The assessment of pathological changes in cerebral blood flow in hypertensive rats with stress-induced intracranial hemorrhage using Doppler OCT: Particularities of arterial and venous alterations/Die Beurteilung von pathologischen Veränderungen der Hirndurchblutung bei hypertensiven Ratten mit Stress-induzierten intrakraniellen Blutungen mittels Doppler-OCT: Besonderheiten von arteriellen und venösen Veränderungen
| العنوان: | The assessment of pathological changes in cerebral blood flow in hypertensive rats with stress-induced intracranial hemorrhage using Doppler OCT: Particularities of arterial and venous alterations/Die Beurteilung von pathologischen Veränderungen der Hirndurchblutung bei hypertensiven Ratten mit Stress-induzierten intrakraniellen Blutungen mittels Doppler-OCT: Besonderheiten von arteriellen und venösen Veränderungen |
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| المؤلفون: | Semyachkina-Glushkovskaya, Oxana V., Lychagov, Vladislav V., Bibikova, Olga A., Semyachkin-Glushkovskiy, Igor A., Sindeev, Sergey S., Zinchenko, Ekaterina M., Kassim, Mohhanad M., Braun, Hans A., Al-Fatle, Fatema, Al Hassani, Leith, Tuchin, Valery V. |
| المصدر: | Photonics & Lasers in Medicine ; volume 2, issue 2 ; ISSN 2193-0643 2193-0635 |
| بيانات النشر: | Walter de Gruyter GmbH |
| سنة النشر: | 2013 |
| الوصف: | Hemorrhagic insult is a major source of morbidity and mortality in both adults and newborn babies in the developed countries. The mechanisms underlying the non-traumatic rupture of cerebral vessels are not fully clear, but there is strong evidence that stress, which is associated with an increase in arterial blood pressure, plays a crucial role in the development of acute intracranial hemorrhage (ICH), and alterations in cerebral blood flow (CBF) may contribute to the pathogenesis of ICH. The problem is that there are no effective diagnostic methods that allow for a prognosis of risk to be made for the development of ICH. Therefore, quantitative assessment of CBF may significantly advance the understanding of the nature of ICH. The aim of this study was to determine the particularities of alterations in arterial and venous cerebral circulation in hypertensive rats at different stages of stress-related development of ICH using three-dimensional Doppler optical coherence tomography (DOCT). Experiments were performed in mongrel adult rats. To induce ICH, hypertensive rats underwent stress (effect of severe sound, 120 dB during 2 h). To induce the renal hypertension (two kidneys, one clip) the rats were clipped at the left renal artery with a silver clip. Seven weeks after clipping, the hypertensive rats were used in the experiment. The monitoring of CBF was performed in anesthetized rats with fixed heads using a commercially available swept source OCT system (OCS1300SS; Thorlabs) in the masked period of ICH (4 h after stress) and during ICH (24 h after stress). It could be shown that in stressed rats, compared with non-stressed animals, the latent stage of stress-induced ICH (4 h after stress-off) is characterized by an increase in diameter of the superior sagittal vein with decrease in speed of the blood flow in the venous network, whereas no changes in the CBF in the arterial tree were found in this period. These facts suggest that the masked period of ICH is accompanied by decreasing venous outflow and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1515/plm-2013-0009 |
| DOI: | 10.1515/plm-2013-0009/pdf |
| الاتاحة: | http://dx.doi.org/10.1515/plm-2013-0009 https://www.degruyter.com/document/doi/10.1515/plm-2013-0009/pdf |
| رقم الانضمام: | edsbas.8E0205D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1515/plm-2013-0009 |
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