التفاصيل البيبلوغرافية
| العنوان: |
Constitutive expression of mPGES-1 in DU145 PCa cells is reduced by KH176m. |
| المؤلفون: |
Xiaolan Jiang (408276), Herma Renkema (11105122), Jan Smeitink (3455747), Julien Beyrath (4516507) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, DU, sonlicromanol metabolite KH 176m, cancer spheroid growth Aggressiveness, metabolite KH 176m normalizes prost., KH 176m, LNCaP cell line, exogenous PGE 2, novel treatment approach, CSC, prostaglandin E synthase, prostate cancer cells-derived spher., mPGES, expression |
| الوصف: |
Human prostate cancer cells (DU145 and LNCaP) were grown in monolayer cultures. Protein was isolated and separated by SDS-PAGE and expression of mPGES-1 was analyzed by western blot. (A) DU145 cells have higher levels of mPGES-1 protein as compared to LNCaP cells (n = 3). (B) mPGES-1 expression is reduced in DU145 cells treated with increasing concentrations of KH176m for 24 h as compared to vehicle treatment (0.1% DMSO) (n = 3). **, p<0 . 005 ; ***, p<0 . 001 ; significant differences compared with the LNCaP or DU145-Veh. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Constitutive_expression_of_mPGES-1_in_DU145_PCa_cells_is_reduced_by_KH176m_/14940259 |
| DOI: |
10.1371/journal.pone.0254315.g001 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0254315.g001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.8DFFC9D2 |
| قاعدة البيانات: |
BASE |