Academic Journal
A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601).
| العنوان: | A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601). |
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| المؤلفون: | KAIDA Sachiko, MIYAKE Toru, MURATA Satoshi, YAMAGUCHI Tsuyoshi, TATSUTA Takeshi, MURAKAMI Koichiro, OKAUCHI Hiroshi, NISHIMURA Shoichi, OHTA Hiroyuki, TSUCHIHASHI Hiroshi, KAWASAKI Masayasu, TAKEBAYASHI Katsushi, SHIMIZU Tomoharu, TANI Masaji, 貝田 佐知子, 三宅 亨, 村田 聡, 山口 剛, 龍田 健, 村上 耕一郎, 岡内 博, 西村 彰一, 太田 裕之, 土橋 洋史, 川崎 誠康, 竹林 克士, 清水 智治, 谷 眞至 |
| سنة النشر: | 2021 |
| المجموعة: | Shiga University of Medical Science Repository BI WAKO / 滋賀医科大学機関リポジトリ |
| مصطلحات موضوعية: | D-dimer, Gastrectomy, Gastric cancer, Soluble fibrin, Venous thromboembolism (VTE) |
| الوصف: | Introduction:This study aimed to clarify the frequency and risk factors of intercurrent venous thromboembolism (VTE) in patients undergoing major curative gastric cancer surgery. ; Methods:This prospective, multicenter, observational study included patients with gastric cancer who underwent radical gastrectomy at 5 hospitals between June 2016 and May 2018. Patients who were preoperatively administered anticoagulants were excluded. ; Results:A total of 126 patients were eligible to participate. VTE occurred within 9 days postoperatively in 5 cases (4.0%; 2 symptomatic and 3 asymptomatic). Postoperative day (POD) 1 plasma D-dimer and soluble fibrin (SF) levels were significantly higher in the VTE group than in the non-VTE group. Receiver-operating characteristic curve (ROC) analysis indicated a statistically significant ability of POD 1 D-dimer and SF levels to predict postoperative VTE development after gastrectomy; this finding was reflected by an area under the curve (AUC) of 0.97 (95% CI 0.92-1.0) and 0.87 (95% CI 0.74-1.0), respectively. Cutoff values of D-dimer (24.6 µg/mL) and SF (64.1 µg/mL) were determined. Intraoperative blood transfusion (odds ratio [OR] 7.86), POD 1 D-dimer ≥24.6 µg/mL (OR 17.35), and POD 1 SF ≥64.1 µg/mL (OR 19.5) were independent predictive factors for postoperative VTE (p < 0.05). ; Conclusion:VTE occurred in 4.0% patients (1.6% symptomatic and 2.4% asymptomatic) after gastric cancer surgery; however, with an early diagnosis and anticoagulant therapy, no patients experienced progression. Careful observation of patients with a high risk for VTE, including intraoperative blood transfusion and high POD 1 D-dimer or SF levels, would contribute to the early detection of VTE. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 1421-9921 |
| Relation: | https://doi.org/10.1159/000514309; https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3820; http://hdl.handle.net/10422/00012930; European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1-10(2021-03-03); https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3820&item_no=1&attribute_id=17&file_no=1 |
| الاتاحة: | http://hdl.handle.net/10422/00012930 https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3820 https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3820&item_no=1&attribute_id=17&file_no=1 |
| Rights: | © 2021 The Author(s) Published by S. Karger AG, Basel. |
| رقم الانضمام: | edsbas.8DF21370 |
| قاعدة البيانات: | BASE |
| تدمد: | 14219921 |
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