التفاصيل البيبلوغرافية
| العنوان: |
Preterm birth leads to impaired rich-club organization and fronto-paralimbic/limbic structural connectivity in newborns |
| المؤلفون: |
Alves Sa De Almeida, Joana Rita, Meskaldji, Djalel Eddine, Loukas, Serafeim, Lordier, Lara, Gui Levy, Laura, Lazeyras, François, Hüppi, Petra Susan |
| المصدر: |
ISSN: 1053-8119 ; NeuroImage, vol. 225 (2021) 117440. |
| سنة النشر: |
2021 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/616.0757, info:eu-repo/classification/ddc/618, Brain/diagnostic imaging/growth & development/physiopathology, Case-Control Studies, Connectome, Female, Functional Neuroimaging, Gestational Age, Gyrus Cinguli/diagnostic imaging/growth & development/physiopathology, Humans, Infant, Newborn, Premature, Magnetic Resonance Imaging, Male, Neural Pathways/diagnostic imaging/growth & development/physiopathology, Parietal Lobe/diagnostic imaging/growth & development/physiopathology, Thalamus/diagnostic imaging/growth & development/physiopathology |
| الوصف: |
Prematurity disrupts brain development during a critical period of brain growth and organization and is known to be associated with an increased risk of neurodevelopmental impairments. Investigating whole-brain structural connectivity alterations accompanying preterm birth may provide a better comprehension of the neurobiological mechanisms related to the later neurocognitive deficits observed in this population. Using a connectome approach, we aimed to study the impact of prematurity on neonatal whole-brain structural network organization at term-equivalent age. In this cohort study, twenty-four very preterm infants at term-equivalent age (VPT-TEA) and fourteen full-term (FT) newborns underwent a brain MRI exam at term age, comprising T2-weighted imaging and diffusion MRI, used to reconstruct brain connectomes by applying probabilistic constrained spherical deconvolution whole-brain tractography. The topological properties of brain networks were quantified through a graph-theoretical approach. Furthermore, edge-wise connectivity strength was compared between groups. Overall, VPT-TEA infants' brain networks evidenced increased segregation and decreased integration capacity, revealed by an increased clustering coefficient, increased modularity, increased characteristic path length, decreased global efficiency and diminished rich-club coefficient. Furthermore, in comparison to FT, VPT-TEA infants had decreased connectivity strength in various cortico-cortical, cortico-subcortical and intra-subcortical networks, the majority of them being intra-hemispheric fronto-paralimbic and fronto-limbic. Inter-hemispheric connectivity was also decreased in VPT-TEA infants, namely through connections linking to the left precuneus or left dorsal cingulate gyrus - two regions that were found to be hubs in FT but not in VPT-TEA infants. Moreover, posterior regions from Default-Mode-Network (DMN), namely precuneus and posterior cingulate gyrus, had decreased structural connectivity in VPT-TEA group. Our finding that VPT-TEA ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33039621; info:eu-repo/grantAgreement/EC/H2020/666992/EU/Data-driven models for Progression Of Neurological Disease/EuroPOND; https://archive-ouverte.unige.ch/unige:155481; unige:155481 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:155481 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.8DC94899 |
| قاعدة البيانات: |
BASE |