Academic Journal
Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.
| العنوان: | Ancestry as a potential modifier of gene expression in breast tumors from Colombian women. |
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| المؤلفون: | Silvia J Serrano-Gómez, María Carolina Sanabria-Salas, Jone Garay, Melody C Baddoo, Gustavo Hernández-Suarez, Juan Carlos Mejía, Oscar García, Lucio Miele, Laura Fejerman, Jovanny Zabaleta |
| المصدر: | PLoS ONE, Vol 12, Iss 8, p e0183179 (2017) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Hispanic/Latino populations are a genetically admixed and heterogeneous group, with variable fractions of European, Indigenous American and African ancestries. The molecular profile of breast cancer has been widely described in non-Hispanic Whites but equivalent knowledge is lacking in Hispanic/Latinas. We have previously reported that the most prevalent breast cancer intrinsic subtype in Colombian women was Luminal B as defined by St. Gallen 2013 criteria. In this study we explored ancestry-associated differences in molecular profiles of Luminal B tumors among these highly admixed women.We performed whole-transcriptome RNA-seq analysis in 42 Luminal tumors (21 Luminal A and 21 Luminal B) from Colombian women. Genetic ancestry was estimated from a panel of 80 ancestry-informative markers (AIM). We categorized patients according to Luminal subtype and to the proportion of European and Indigenous American ancestry and performed differential expression analysis comparing Luminal B against Luminal A tumors according to the assigned ancestry groups.We found 5 genes potentially modulated by genetic ancestry: ERBB2 (log2FC = 2.367, padj<0.01), GRB7 (log2FC = 2.327, padj<0.01), GSDMB (log2FC = 1.723, padj<0.01, MIEN1 (log2FC = 2.195, padj<0.01 and ONECUT2 (log2FC = 2.204, padj<0.01). In the replication set we found a statistical significant association between ERBB2 expression with Indigenous American ancestry (p = 0.02, B = 3.11). This association was not biased by the distribution of HER2+ tumors among the groups analyzed.Our results suggest that genetic ancestry in Hispanic/Latina women might modify ERBB2 gene expression in Luminal tumors. Further analyses are needed to confirm these findings and explore their prognostic value. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC5568388?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/5e7bcceb498d4e40980a8746d3b5f970 |
| DOI: | 10.1371/journal.pone.0183179 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0183179 https://doaj.org/article/5e7bcceb498d4e40980a8746d3b5f970 |
| رقم الانضمام: | edsbas.8DC15700 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0183179 |