التفاصيل البيبلوغرافية
| العنوان: |
Lack of influence of the ACE1 gene I/D polymorphism on the formation and growth of benign uterine leiomyoma in turkish patients |
| المؤلفون: |
Gültekin, G.I., Yilmaz, S.G., Kahraman, Ö.T., Atasoy, H., Burak Dalan, A., Attar, Rukset, İşbir, Turgay |
| المساهمون: |
Gültekin, G.I., Yilmaz, S.G., Kahraman, Ö.T., Atasoy, H., Burak Dalan, A., Attar, Rukset, İşbir, Turgay, Yeditepe Üniversitesi |
| بيانات النشر: |
Asian Pacific Organization for Cancer Prevention |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
ACE insertion/deletion, Angiogenesis, Benign cancer, Uterine fibroid, Uterine myoma |
| الوصف: |
Uterine leiomyomas (ULM), are benign tumors of the smooth muscle cells of the myometrium. They represent a common health problem and are estimated to be present in 30-70% of clinically reproductive women. Abnormal angiogenesis and vascular-related growth factors have been suggested to be associated with ULM growth. The angiotensin-I converting enzyme (ACE) is related with several tumors. The aim of this study was to identify possible correlation between ULM and the ACE I/D polymorphism, to evaluate whether the ACE I/D polymorphism could be a marker for early diagnosis and prognosis. ACE I/D was amplified with specific primer sets recognizing genomic DNA from ULM (n=72) and control (n=83) volunteers and amplicons were separated on agarose gels. The observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium (?2=2.162, p=0.339). There was no association between allele frequencies and study groups (?2=0.623; p=0.430 for ACE I allele, ?2=0.995; p=0.339 for ACE D allele). In addition, there were no significant differences between ACE I/D polymorphism genotype frequencies and ULM range in size and number (?2=1.760; p=0.415 for fibroid size, ?2=0.342; p=0.843 for fibroid number). We conclude that the ACE gene I/D polymorphism is not related with the size or number of ULM fibroids in Turkish women. Thus it cannot be regarded as an early diagnostic parameter nor as a risk estimate for ULM predisposition. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
15137368 |
| Relation: |
Asian Pacific Journal of Cancer Prevention; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; PubMed ID: 25735342; 1123; 1127; 16; https://hdl.handle.net/20.500.11831/3473 |
| الاتاحة: |
https://hdl.handle.net/20.500.11831/3473 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.8DACA16 |
| قاعدة البيانات: |
BASE |
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