التفاصيل البيبلوغرافية
| العنوان: |
Erythropoietin Does Not Alter Serum Profiles of Neuronal and Axonal Biomarkers After Traumatic Brain Injury: Findings From the Australian EPO-TBI Clinical Trial |
| المؤلفون: |
Hellewell, SC, Mondello, S, Conquest, A, Shaw, G, Madorsky, I, Deng, JV, Little, L, Kobeissy, F, Nicole Bye, Bellomo, R, Cooper, DJ, Vallance, S, Board, J, Morganti-Kossmann, MC |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
Central nervous system, traumatic brain injury, serum biomarkers, erythropoietin |
| الوصف: |
Objective: To determine profiles of serum ubiquitin carboxy-terminal hydrolase L1 and phosphorylated neurofilament heavy-chain, examine whether erythropoietin administration reduce their concentrations, and whether biomarkers discriminate between erythropoietin and placebo treatment groups. Design: Single-center, prospective observational study. Setting: A sub-study of the erythropoietin-traumatic brain injury clinical trial, conducted at the Alfred Hospital, Melbourne, Australia. Patients: Forty-four patients with moderate-to-severe traumatic brain injury. Interventions: Epoetin alfa 40,000 IU or 1mL sodium chloride 0.9 as subcutaneous injection within 24 hours of traumatic brain injury. Measurements and Main Results: Ubiquitin carboxy-terminal hydrolase L1, phosphorylated neurofilament heavy-chain, and erythropoietin concentrations were measured in serum by enzyme-linked immunosorbent assay from D0 (within 24hr of injury, prior to erythropoietin/vehicle administration) to D5. Biomarker concentrations were compared between injury severities, diffuse versus focal traumatic brain injury and erythropoietin or placebo treatment groups. Ubiquitin carboxy-terminal hydrolase L1 peaked at 146.0ng/mL on D0, significantly decreased to 84.30ng/mL on D1, and declined thereafter. Phosphorylated neurofilament heavy-chain levels were lowest at D0 and peaked on D5 at 157.9ng/mL. D0 ubiquitin carboxy-terminal hydrolase L1 concentrations were higher in diffuse traumatic brain injury. Peak phosphorylated neurofilament heavy-chain levels on D3 and D4 correlated with Glasgow Outcome Score–Extended, predicting poor outcome. Erythropoietin did not reduce concentrations of ubiquitin carboxy-terminal hydrolase L1 or phosphorylated neurofilament heavy-chain. Conclusions: Serum ubiquitin carboxy-terminal hydrolase L1 and phosphorylated neurofilament heavy-chain increase after traumatic brain injury reflecting early neuronal and progressive axonal injury. Consistent with lack of improved outcome in traumatic brain injury patients treated ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
102.100.100/563350; https://figshare.com/articles/journal_contribution/Erythropoietin_Does_Not_Alter_Serum_Profiles_of_Neuronal_and_Axonal_Biomarkers_After_Traumatic_Brain_Injury_Findings_From_the_Australian_EPO-TBI_Clinical_Trial/22963445 |
| الاتاحة: |
https://figshare.com/articles/journal_contribution/Erythropoietin_Does_Not_Alter_Serum_Profiles_of_Neuronal_and_Axonal_Biomarkers_After_Traumatic_Brain_Injury_Findings_From_the_Australian_EPO-TBI_Clinical_Trial/22963445 |
| Rights: |
In Copyright |
| رقم الانضمام: |
edsbas.8D945786 |
| قاعدة البيانات: |
BASE |