Academic Journal
In-situ X-ray imaging of sublimating spin-frozen solutions
| العنوان: | In-situ X-ray imaging of sublimating spin-frozen solutions |
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| المؤلفون: | Goethals, Wannes, Vanbillemont, Brecht, Lammens, Joris, De Beer, Thomas, Vervaet, Chris, Boone, Matthieu |
| المصدر: | MATERIALS ; ISSN: 1996-1944 |
| سنة النشر: | 2020 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Technology and Engineering, Chemistry, Physics and Astronomy, X-ray micro-CT, dynamic imaging, in-situ imaging, spin-freezing, freeze-drying, MICRO-CT, HAINES JUMPS, FREEZE, TOMOGRAPHY |
| الوصف: | Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/8668950; http://doi.org/10.3390/ma13132953; https://biblio.ugent.be/publication/8668950/file/8668955 |
| DOI: | 10.3390/ma13132953 |
| الاتاحة: | https://biblio.ugent.be/publication/8668950 http://hdl.handle.net/1854/LU-8668950 https://doi.org/10.3390/ma13132953 https://biblio.ugent.be/publication/8668950/file/8668955 |
| Rights: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8D82EFDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ma13132953 |
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