Academic Journal
Use of personal care products during pregnancy in relation to urinary concentrations of select phenols: A longitudinal analysis from the SEPAGES feasibility study
| العنوان: | Use of personal care products during pregnancy in relation to urinary concentrations of select phenols: A longitudinal analysis from the SEPAGES feasibility study |
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| المؤلفون: | Nakiwala, Dorothy, Vernet, Céline, Lyon-Caen, Sarah, Lavorel, Anna, Rolland, Matthieu, Cracowski, Claire, Pin, Isabelle, Calafat, Antonia, M, Slama, Rémy, Philippat, Claire, Eyriey, E., Licinia, A., Vellement, A., Hoffmann, P., Hullo, E., Llerena, C., Morin, X., Morlot, A., Lepeule, J., Quentin, J., Siroux, V. |
| المساهمون: | Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Service d'hospitalisation Urgences Pneumologiques - Mucoviscidose Adulte, Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon, Centers for Disease Control and Prevention Atlanta (CDC), Centers for Disease Control and Prevention, ANR-19-CE36-0003,EDeN,Exposition précoces aux perturbateurs endocriniens et neurodéveloppement de l'enfant : le rôle de l'axe hypothalamo-hypophysaire(2019) |
| المصدر: | ISSN: 1438-4639 ; International Journal of Hygiene and Environmental Health ; https://hal.science/hal-02547829 ; International Journal of Hygiene and Environmental Health, 2020, 227, pp.113518. ⟨10.1016/j.ijheh.2020.113518⟩. |
| بيانات النشر: | CCSD Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Université Grenoble Alpes: HAL |
| مصطلحات موضوعية: | Personal care products, Endocrine disruptors, Pregnant women, Benzophenone-3, Bisphenols, Parabens, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health |
| الوصف: | International audience ; Background: Exposure to certain synthetic phenols is of growing concern, in particular among pregnant women, because of their endocrine disrupting nature. Many phenols are still authorized in personal care products (PCP). We aimed to assess if use of PCPs, by pregnant women could influence their urinary concentrations of synthetic phenols.Methods: We used a panel design with intense urine sample collection. Eight women completed a diary with exact time and use of PCPs in three weeks. We measured the concentrations of phenols (four parabens, bisphenol A and S, two dichlorophenols, triclosan, and benzophenone-3) in 178 urine samples, collected during 7 consecutive days at 3 time points during pregnancy. We characterized PCP use as the total number of PCP applications or as a single PCP use (yes/no) in three time windows (0–6, 6 to 12 and 12 to 24h before each urine sample collection). We used adjusted linear and Tobit regressions to assess associations between PCP use and phenol urinary concentrations.Results: The total number of PCP applications was positively associated with ethylparaben, propylparaben and butylparaben concentrations. We observed a peak in urinary concentration of ethylparaben, butylparaben and propylparaben at 2.86, 2.55 and 2.67 h since last PCP use, respectively and twelve different types of PCPs were positively associated with at least one of these parabens. The bisphenol S concentration increased by 12.4% (95%CI: confidence interval: 5.9; 19.3) for each additional PCP application in the 12 to 24 time window and use of specific PCPs such as anti-stretchmarks cream, facial cleanser and shower gel. Associations varied by time window.Conclusion: Our study showed that PCP use was associated with a short-term increase in the urinary concentration of ethylparaben, butylparaben and propylparaben, but not methylparaben. This study also reported a positive association between the use of PCPs and the bisphenol S concentration, a finding that warrants further investigation in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.ijheh.2020.113518 |
| الاتاحة: | https://hal.science/hal-02547829 https://hal.science/hal-02547829v1/document https://hal.science/hal-02547829v1/file/Nakiwala%20et%20al.%20-%202020%20-%20Use%20of%20personal%20care%20products%20during%20pregnancy%20in%20.pdf https://doi.org/10.1016/j.ijheh.2020.113518 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8D0F9E16 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijheh.2020.113518 |
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