Academic Journal
Immunogenomic profile at baseline predicts host susceptibility to clinical malaria
| العنوان: | Immunogenomic profile at baseline predicts host susceptibility to clinical malaria |
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| المؤلفون: | Mbambo, Gillian, Dwivedi, Ankit, Ifeonu, Olukemi O., Munro, James B., Shrestha, Biraj, Bromley, Robin E., Hodges, Theresa, Adkins, Ricky S., Kouriba, Bourema, Diarra, Issa, Niangaly, Amadou, Kone, Abdoulaye K., Coulibaly, Drissa, Traore, Karim, Dolo, Amagana, Thera, Mahamadou A., Laurens, Matthew B., Doumbo, Ogobara K., Plowe, Christopher V., Berry, Andrea A., Travassos, Mark, Lyke, Kirsten E., Silva, Joana C. |
| المساهمون: | Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Vector borne diseases and pathogens (VBD) |
| سنة النشر: | 2023 |
| المجموعة: | Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: | baseline immunity, human parasite immunology, immunoinformatic analysis, malaria immunity, malaria susceptibility, mass cytometrý, RNA sequencing, QR180 Immunology, QR Microbiology, Immunology, Parasitology, Biochemistry, Genetics and Molecular Biology(all), SDG 3 - Good Health and Well-being |
| الوصف: | Funding Information: This project was funded in part by federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under grant number U19AI110820. Site development and the conduct of the original clinical trial were supported by contract N01AI85346 and cooperative agreement U19AI065683 from the National Institute of Allergy and Infectious Diseases, grant D43TW001589 from the Fogarty International Center, National Institutes of Health and contract W81XWH-06-1-0427 from the United States Department of Defense and the United States Agency for International Development for site development and the conduct of the trial. Acknowledgments Publisher Copyright: Copyright © 2023 Mbambo, Dwivedi, Ifeonu, Munro, Shrestha, Bromley, Hodges, Adkins, Kouriba, Diarra, Niangaly, Kone, Coulibaly, Traore, Dolo, Thera, Laurens, Doumbo, Plowe, Berry, Travassos, Lyke and Silva. ; Introduction: Host gene and protein expression impact susceptibility to clinical malaria, but the balance of immune cell populations, cytokines and genes that contributes to protection, remains incompletely understood. Little is known about the determinants of host susceptibility to clinical malaria at a time when acquired immunity is developing. Methods: We analyzed peripheral blood mononuclear cells (PBMCs) collected from children who differed in susceptibility to clinical malaria, all from a small town in Mali. PBMCs were collected from children aged 4-6 years at the start, peak and end of the malaria season. We characterized the immune cell composition and cytokine secretion for a subset of 20 children per timepoint (10 children with no symptomatic malaria age-matched to 10 children with >2 symptomatic malarial illnesses), and gene expression patterns for six children (three per cohort) per timepoint. Results: We observed differences between the two groups of children in the expression of genes related to cell death and inflammation; in particular, inflammatory ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-85-16-51108-1 978-0-01-029809-3 85-16-51108-1 0-01-029809-6 |
| تدمد: | 1664-3224 |
| Relation: | PURE: 83836706; PURE UUID: 899cfc7c-3d80-4535-bd35-fc08327793de; Scopus: 85165110813; PubMed: 37465667; WOS: WOS:001029809600001; http://hdl.handle.net/10362/164498; https://doi.org/10.3389/fimmu.2023.1179314 |
| DOI: | 10.3389/fimmu.2023.1179314 |
| الاتاحة: | http://hdl.handle.net/10362/164498 https://doi.org/10.3389/fimmu.2023.1179314 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.8CE0AB60 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9788516511081 9780010298093 8516511081 0010298096 |
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| تدمد: | 16643224 |
| DOI: | 10.3389/fimmu.2023.1179314 |