Academic Journal
Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice
| العنوان: | Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice |
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| المؤلفون: | Chung, Yoon Hee, Joo, Kyeung Min, Lim, Heon Chang, Cho, Min Haeng, Kim, Daejin, Lee, Won Bok, Cha, Choong Ik |
| المساهمون: | 정윤희, 주경민, 임헌창, 조미행, 김대진, 이원복, 차충익 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2005 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Amyotrophic Lateral Sclerosis/*metabolism/pathology, Animals, Astrocytes/*enzymology/pathology, Central Nervous System/pathology/*physiopathology, Extracellular Signal-Regulated MAP Kinases/*metabolism, Immunohistochemistry, Mice, Inbred Strains, Transgenic, Phosphorylation, Superoxide Dismutase/*genetics |
| الوصف: | In the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (pERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Brain Res. 2005 Jul 19;1050(1-2):203-9.; 0006-8993 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15978558; https://hdl.handle.net/10371/27581 |
| DOI: | 10.1016/j.brainres.2005.05.060 |
| الاتاحة: | https://hdl.handle.net/10371/27581 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15978558 https://doi.org/10.1016/j.brainres.2005.05.060 |
| رقم الانضمام: | edsbas.8CC7F2EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.brainres.2005.05.060 |
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